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    ogt-1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase [ Caenorhabditis elegans ]

    Gene ID: 176000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ogt-1
    Official Full Name
    UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase
    Primary source
    WormBase:WBGene00003858
    Locus tag
    CELE_K04G7.3
    See related
    AllianceGenome:WB:WBGene00003858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein N-acetylglucosaminyltransferase activity; protein O-acetylglucosaminyltransferase activity; and protein serine/threonine phosphatase activity. Involved in several processes, including dauer larval development; glycogen metabolic process; and lipid storage. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including intestine. Used to study diabetes mellitus and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ogt-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (7145842..7153797, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Glutamate receptor 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Deoxynucleoside kinase domain-containing protein;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial Neighboring gene U1 small nuclear ribonucleoprotein 70 kDa

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans. Yadav DK, et al. Elife, 2024 Feb 9. PMID 38334260, Free PMC Article
    2. Nutrient-Driven O-GlcNAcylation at Promoters Impacts Genome-Wide RNA Pol II Distribution. Krause MW, et al. Front Endocrinol (Lausanne), 2018. PMID 30250452, Free PMC Article
    3. Identification and correction of abnormal, incomplete and mispredicted proteins in public databases. Nagy A, et al. BMC Bioinformatics, 2008 Aug 27. PMID 18752676, Free PMC Article
    4. A critical perspective of the diverse roles of O-GlcNAc transferase in chromatin. Gambetta MC, et al. Chromosoma, 2015 Dec. PMID 25894967, Free PMC Article
    5. ELT-2 promotes O-GlcNAc transferase OGT-1 expression to modulate Caenorhabditis elegans lifespan. Su L, et al. J Cell Biochem, 2020 Dec. PMID 32628333

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OGT-1 regulates synaptic assembly through the insulin signaling pathway.
      Title: OGT-1 regulates synaptic assembly through the insulin signaling pathway.
    2. O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
      Title: O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
    3. The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress.
      Title: The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress.
    4. findings demonstrate that OGT-1 and EEL-1 form a conserved signaling complex and function together to affect GABA neuron function
      Title: A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function.
    5. The Caenorhabditis elegans orthologues of Ca(2+)/calmodulin-dependent kinases CaMK1/4, CMK-1, and O-linked N-acetylglucosamine (O-GlcNAc) transferase, OGT-1, both function in primary sensory neurons to inhibit habituation at short interstimulus interval (ISI) and promote it at long ISIs.
      Title: Insights into the roles of CMK-1 and OGT-1 in interstimulus interval-dependent habituation in Caenorhabditis elegans.
    6. The participation of nutrient sensor OGT-1 in an immunity module evolutionarily conserved from C. elegans to humans reveals an unexplored nexus between nutrient availability and a pathogen-specific immune response.
      Title: Conserved nutrient sensor O-GlcNAc transferase is integral to C. elegans pathogen-specific immunity.
    7. Data show that glucose stress, oga-1 mutants, and ogt-1 mutants each result in an increase in daf-2 carbohydrate storage.
      Title: O-linked-N-acetylglucosamine cycling and insulin signaling are required for the glucose stress response in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein N-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein N-acetylglucosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein O-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein O-acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UDP-N-acetylglucosamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in energy reserve metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase;protein O-GlcNAc transferase
    NP_001040860.1
    • Confirmed by transcript evidence
    NP_001040861.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7145842..7153797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047395.5 → NP_001040860.1  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040860.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18158, Q21232
      Conserved Domains (8) summary
      COG0457
      Location:308 → 565
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:465 → 493
      TPR; TPR repeat [structural motif]
      cd15832
      Location:330 → 375
      SNAP; TPR repeat [structural motif]
      pfam00515
      Location:499 → 530
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:193 → 258
      TPR_11; TPR repeat
      pfam13424
      Location:257 → 327
      TPR_12; Tetratricopeptide repeat
      pfam13844
      Location:663 → 1129
      Glyco_transf_41; Glycosyl transferase family 41
      cl24038
      Location:330 → 534
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    2. NM_001047396.5 → NP_001040861.1  protein O-GlcNAc transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040861.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2L6Y4
      Conserved Domains (3) summary
      TIGR02917
      Location:21 → 422
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:287 → 315
      TPR; TPR repeat [structural motif]
      pfam13844
      Location:485 → 951
      Glyco_transf_41; Glycosyl transferase family 41
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18158.2

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