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    F32D8.5 Transmembrane protein 70 homolog, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 179509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F32D8.5
    Official Full Name
    Transmembrane protein 70 homolog, mitochondrial
    Primary source
    WormBase:WBGene00009330
    Locus tag
    CELE_F32D8.5
    See related
    AllianceGenome:WB:WBGene00009330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to be located in membrane. Predicted to be active in mitochondrial membrane. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Orthologous to human TMEM70 (transmembrane protein 70). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F32D8.5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (10894800..10895953)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene PIH1 N-terminal domain-containing protein Neighboring gene Protein YIPF Neighboring gene Phosphomevalonate kinase Neighboring gene Protein transport protein Sec61 subunit gamma Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Saposin B-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane protein 70 homolog, mitochondrial
    NP_505776.1
    • Partially confirmed by transcript evidence
    NP_505777.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10894800..10895953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073376.6 → NP_505777.1  Transmembrane protein 70 homolog, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505777.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19966
      Conserved Domains (1) summary
      pfam06979
      Location:77 → 198
      TMEM70; Assembly, mitochondrial proton-transport ATP synth complex

    2. NM_073375.6 → NP_505776.1  Transmembrane protein 70 homolog, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505776.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3H0
      Conserved Domains (1) summary
      pfam06979
      Location:79 → 200
      TMEM70; Assembly, mitochondrial proton-transport ATP synth complex
    Nucleotide Protein
    Heading Accession and Version

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