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    cwf-19L1 CWF19-like protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 179000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cwf-19L1
    Official Full Name
    CWF19-like protein 1 homolog
    Primary source
    WormBase:WBGene00017534
    Locus tag
    CELE_F17A9.2
    See related
    AllianceGenome:WB:WBGene00017534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA lariat debranching enzyme activator activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 17. Orthologous to human CWF19L1 (CWF19 like cell cycle control factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cwf-19L1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (6107828..6114856)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DNA-directed DNA polymerase Neighboring gene ncRNA Neighboring gene BZIP domain-containing protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein Neighboring gene pseudo Neighboring gene One cut domain family member

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA lariat debranching enzyme activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CWF19-like protein 1 homolog
    NP_504577.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6107828..6114856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072176.7 → NP_504577.1  CWF19-like protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16216
      Conserved Domains (3) summary
      cd07380
      Location:9 → 222
      MPP_CWF19_N; Schizosaccharomyces pombe CWF19 and related proteins, N-terminal metallophosphatase domain
      pfam04676
      Location:444 → 527
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      pfam04677
      Location:309 → 417
      CwfJ_C_1; Protein similar to CwfJ C-terminus 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16216.2

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