U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    irg-5 CUB-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185307, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    irg-5
    Official Full Name
    CUB-like domain-containing protein
    Primary source
    WormBase:WBGene00009429
    Locus tag
    CELE_F35E12.5
    See related
    AllianceGenome:WB:WBGene00009429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-positive bacterium. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See irg-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (13737010..13738474, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CUB-like domain-containing protein Neighboring gene CUB-like domain-containing protein;CUB_2 domain-containing protein Neighboring gene CUB-like domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The alkaloid compound harmane increases the lifespan of Caenorhabditis elegans during bacterial infection, by modulating the nematode's innate immune response. Jakobsen H, et al. PLoS One, 2013. PMID 23544153, Free PMC Article
    2. A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. Bolz DD, et al. J Biol Chem, 2010 Apr 2. PMID 20133945, Free PMC Article
    3. Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans. Cornejo Castro EM, et al. J Neural Transm (Vienna), 2010 May. PMID 20376509
    4. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. Pukkila-Worley R, et al. PLoS Genet, 2012. PMID 22719261, Free PMC Article
    5. A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans. Reddy KC, et al. Science, 2009 Jan 16. PMID 19150845, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CUB-like domain-containing protein
    NP_001366887.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13737010..13738474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380807.2 → NP_001366887.1  CUB-like domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O02357
      Conserved Domains (2) summary
      pfam02408
      Location:17 → 127
      CUB_2; CUB-like domain
      pfam14781
      Location:209 → 278
      BBS2_N; Ciliary BBSome complex subunit 2, N-terminal
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools