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    atg-4.2 Cysteine protease atg-4.2 [ Caenorhabditis elegans ]

    Gene ID: 3565022, updated on 2-Nov-2024

    Summary

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    Official Symbol
    atg-4.2
    Official Full Name
    Cysteine protease atg-4.2
    Primary source
    WormBase:WBGene00014080
    Locus tag
    CELE_ZK792.8
    See related
    AllianceGenome:WB:WBGene00014080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cysteine-type endopeptidase activity. Predicted to be involved in macroautophagy and protein processing. Predicted to be active in cytoplasm. Is expressed in embryonic cell; gonad; and oocyte. Orthologous to several human genes including ATG4D (autophagy related 4D cysteine peptidase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See atg-4.2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    10
    Sequence:
    Chromosome: IV; NC_003282.8 (11668024..11671505)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Acid phosphatase-like protein 2 Neighboring gene 2-phosphoxylose phosphatase 1 Neighboring gene Innexin-8 Neighboring gene Innexin Neighboring gene ANK_REP_REGION domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A specific ATG-4 isoform is required for autophagic maturation and clearance in C. elegans neurons. Hill SE, et al. Autophagy, 2019 Oct. PMID 31291815, Free PMC Article
    2. Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2. Hill SE, et al. Dev Cell, 2019 Apr 22. PMID 30880001, Free PMC Article
    3. Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans. Wu F, et al. J Biol Chem, 2012 Aug 24. PMID 22767594, Free PMC Article
    4. Ginseng volatile oil prolongs the lifespan and healthspan of Caenorhabditis elegans. Wang L, et al. Biogerontology, 2022 Aug. PMID 35939242, Free PMC Article
    5. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Meléndez A, et al. Science, 2003 Sep 5. PMID 12958363

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A specific ATG-4 isoform is required for autophagic maturation and clearance in C. elegans neurons.
      Title: A specific ATG-4 isoform is required for autophagic maturation and clearance in C. elegans neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-phosphatidylethanolamide deconjugating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-phosphatidylethanolamide deconjugating activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aggrephagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cysteine protease atg-4.2
    NP_502208.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11668024..11671505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069807.4 → NP_502208.1  Cysteine protease atg-4.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1N6
      Conserved Domains (1) summary
      pfam03416
      Location:168 → 459
      Peptidase_C54; Peptidase family C54
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U1N6.1

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