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    pen-2 Gamma-secretase subunit pen-2 [ Caenorhabditis elegans ]

    Gene ID: 176565, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pen-2
    Official Full Name
    Gamma-secretase subunit pen-2
    Primary source
    WormBase:WBGene00003975
    Locus tag
    CELE_T28D6.9
    See related
    AllianceGenome:WB:WBGene00003975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including Notch signaling pathway; germ cell development; and pharynx development. Located in membrane. Is expressed in intestine; muscle cell; neurons; and vulva. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pen-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (11343322..11344147)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Protein MCM10 homolog Neighboring gene GTP-binding protein 128up;OBG-type G domain-containing protein Neighboring gene CUB domain-containing protein Neighboring gene START domain-containing protein Neighboring gene tRNA-Val Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Notch signaling without the APH-2/nicastrin subunit of gamma secretase in Caenorhabditis elegans germline stem cells. Brinkley DM, et al. Genetics, 2024 Jul 8. PMID 38717968
    2. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. Edbauer D, et al. J Biol Chem, 2004 Sep 3. PMID 15210705
    3. Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases. Alexander AG, et al. Front Genet, 2014. PMID 25250042, Free PMC Article
    4. Genetics leads the way to the accomplices of presenilins. Goutte C. Dev Cell, 2002 Jul. PMID 12110162
    5. Low-dose metformin targets the lysosomal AMPK pathway through PEN2. Ma T, et al. Nature, 2022 Mar. PMID 35197629, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Notch receptor processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of gamma-secretase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-secretase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gamma-secretase subunit pen-2
    NP_499459.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11343322..11344147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067058.6 → NP_499459.1  Gamma-secretase subunit pen-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U357
      Conserved Domains (1) summary
      pfam10251
      Location:7 → 99
      PEN-2; Presenilin enhancer-2 subunit of gamma secretase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U357.1

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