nhr-86 Nuclear hormone receptor family member nhr-86 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nhr-86
Official Full Name: Nuclear hormone receptor family member nhr-86
Primary source: WormBase:WBGene00003676
Locus tag: CELE_Y40B10A.8
See related: AllianceGenome:WB:WBGene00003676
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in hypodermis and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhr-86 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (2061106..2066850, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NHR-86 by this compound drives a transcriptional program that provides protection against this pathogen. Interestingly, NHR-86 targets immune effectors whose basal regulation requires the canonical p38 MAPK PMK-1 immune pathway. However, NHR-86 functions independently of PMK-1 and modulates the transcription of these infection response genes directly.
Title: The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nuclear hormone receptor family member nhr-86

NP_001368574.1

Confirmed by transcript evidence

NP_503561.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

2061106..2066850 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380613.1 → NP_001368574.1 Nuclear hormone receptor family member nhr-86 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AVA9, Q9GTD3

Conserved Domains (2) summary

cd06157
Location:187 → 372

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

smart00399
Location:23 → 91

ZnF_C4; c4 zinc finger in nuclear hormone receptors
NM_071160.9 → NP_503561.2 Nuclear hormone receptor family member nhr-86 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503561.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q965W2, Q9GTD1

UniProtKB/TrEMBL

Q9GTD3

Conserved Domains (2) summary

cd06157
Location:187 → 375

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

smart00399
Location:23 → 91

ZnF_C4; c4 zinc finger in nuclear hormone receptors