comt-3 Catechol O-methyltransferase domain-containing protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: comt-3
Official Full Name: Catechol O-methyltransferase domain-containing protein 1
Primary source: WormBase:WBGene00021487
Locus tag: CELE_Y40B10A.2
See related: AllianceGenome:WB:WBGene00021487
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in methylation. Orthologous to human COMTD1 (catechol-O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See comt-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (2057537..2061136)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y40B10A.g (e-PCR)
- UniSTS:323926

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-adenosylmethionine-dependent methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Catechol O-methyltransferase domain-containing protein 1

NP_001300240.1

Confirmed by transcript evidence

NP_503560.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

2057537..2061136

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071159.7 → NP_503560.2 Catechol O-methyltransferase domain-containing protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503560.2

Status: REVIEWED

UniProtKB/TrEMBL

Q965W3

Conserved Domains (2) summary

COG4122
Location:16 → 226

YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

cl17173
Location:16 → 225

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
NM_001313311.3 → NP_001300240.1 Catechol O-methyltransferase domain-containing protein 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AT05

Conserved Domains (1) summary

cl17173
Location:3 → 184

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...