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    siah-1 E3 ubiquitin-protein ligase siah-1 [ Caenorhabditis elegans ]

    Gene ID: 177138, updated on 9-Dec-2024

    Summary

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    Official Symbol
    siah-1
    Official Full Name
    E3 ubiquitin-protein ligase siah-1
    Primary source
    WormBase:WBGene00021369
    Locus tag
    CELE_Y37E11AR.2
    See related
    AllianceGenome:WB:WBGene00021369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in programmed cell death involved in cell development. Predicted to be active in cytoplasm. Is expressed in several structures, including anal depressor muscle; excretory cell; intestine; nervous system; and reproductive system. Orthologous to several human genes including SIAH1 (siah E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See siah-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (3744048..3747351)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 1 Neighboring gene ncRNA Neighboring gene glucuronosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Kim H, et al. Mol Cell, 2011 Nov 18. PMID 22099302, Free PMC Article
    2. HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans. Kinet MJ, et al. Elife, 2016 Mar 8. PMID 26952214, Free PMC Article
    3. RSR-2, the Caenorhabditis elegans ortholog of human spliceosomal component SRm300/SRRM2, regulates development by influencing the transcriptional machinery. Fontrodona L, et al. PLoS Genet, 2013 Jun. PMID 23754964, Free PMC Article
    4. TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM. Couillault C, et al. Nat Immunol, 2004 May. PMID 15048112
    5. Functional importance of an inverted formin C-terminal tail at morphologically dynamic epithelial junctions. Hegsted A, et al. Cytoskeleton (Hoboken), 2019 Apr. PMID 31215743, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in programmed cell death involved in cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in programmed cell death involved in cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase siah-1
    NP_500409.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3744048..3747351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068008.6 → NP_500409.1  E3 ubiquitin-protein ligase siah-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46223, Q965X6
      Conserved Domains (2) summary
      cd00162
      Location:155 → 194
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam03145
      Location:197 → 396
      Sina; Seven in absentia protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q965X6.3

    Gene LinkOut

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