hpl-1 Chromobox protein homolog hpl-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hpl-1
Official Full Name: Chromobox protein homolog hpl-1
Primary source: WormBase:WBGene00001995
Locus tag: CELE_K08H2.6
See related: AllianceGenome:WB:WBGene00001995
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables enzyme binding activity and methylated histone binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of vulval development; and positive regulation of growth rate. Located in heterochromatin and nucleus. Is expressed widely. Orthologous to several human genes including CBX3 (chromobox 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hpl-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (13245390..13247044)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression.
Title: Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression.
The heterochromatin protein 1 family proteins HPL-1 and HPL-2 are dispensable for de novo centromerization even though arrays become strongly enriched for the heterochromatin-associated H3K9me3 modification over time.
Title: Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.
Caenorhabditis elegans H1 variant his-24, hpl-1, and hpl-2 coregulate the expression of genes linked to immune response.
Title: Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
These results suggest that HP1 and a SET1/MLL-related complex may play antagonistic roles in the epigenetic regulation of specific developmental programs.
Title: Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development.
Our results show that HPL-1 and HPL-2 play both unique and redundant functions in post-embryonic development.
Title: Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K08H2.6 (e-PCR)
- UniSTS:318331

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in gonad development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of growth rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in reproductive process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IEA Inferred from Electronic Annotation more info
located_in heterochromatin	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Chromobox protein homolog hpl-1

NP_510199.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13245390..13247044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077798.5 → NP_510199.1 Chromobox protein homolog hpl-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510199.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EET5

Conserved Domains (2) summary

smart00300
Location:114 → 174

ChSh; Chromo Shadow Domain

cd18960
Location:36 → 85

CD_HP1_like; chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; uncharacterized subgroup