egl-5 Homeobox protein egl-5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-5
Official Full Name: Homeobox protein egl-5
Primary source: WormBase:WBGene00001174
Locus tag: CELE_C08C3.1
See related: AllianceGenome:WB:WBGene00001174
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including nematode male tail tip morphogenesis; regulation of MAP kinase activity; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including neurons; non-striated muscle; ray precursor cell; rectal epithelial cell; and somatic nervous system. Orthologous to human HOXA7 (homeobox A7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See egl-5 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (7814374..7817141)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here we describe a nonautonomous role of mab-5 in regulating both QR and QL descendant migrations, a role masked by redundancy with lin-39 A third Hox gene, egl-5/Abdominal-B, also likely nonautonomously regulates Q descendant migrations.We find that increased levels of MAB-5 in body wall muscle (BWM) can drive the spon-1 promoter adjacent to the Q cells, and
Title: Nonautonomous Roles of MAB-5/Hox and the Secreted Basement Membrane Molecule SPON-1/F-Spondin in Caenorhabditis elegans Neuronal Migration.
EGL-5 is required for subtype-specific circuit formation in both sensory neurons and interneurons.
Title: Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans.
egl-5 plays an instructive role in male cell fate determination in the C. elegans somatic gonad.
Title: EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad.
The C. elegans Hox gene egl-5 is frequired for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum.
Title: The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum.
microRNAs may contribute to the tight restriction of egl-5 expression to particular cell lineages
Title: Regulation of the Caenorhabditis elegans posterior Hox gene egl-5 by microRNA and the polycomb-like gene sop-2.
bar-1 beta-catenin and egl-5 homeobox genes play an important and conserved role in innate immune defense.
Title: Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
Expression of EGL-5 in the HSN motor neuron/PHB sensory neuron precursor but not in the PHB neuron suggests that EGL-5 specifies precursor fate.
Title: The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage.
Mutating a CCAAT box in the proximal promoter of egl-5 leads to the derepression of egl-5, suggesting a direct role for the NFY complex in the regulation of egl-5.
Title: Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.
Data show that sem-4 indirectly modulates mec-3 expression through its repression of egl-5 and that this negative regulation is required for proper determination of neuronal fates.
Title: The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3.
Data present an analysis of cis-regulatory elements in the Caenorhabditis elegans Hox gene egl-5, which is expressed in multiple tissues in the posterior region of the nematode.
Title: Dissection of cis-regulatory elements in the C. elegans Hox gene egl-5 promoter.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C08C3.1 (e-PCR)
- UniSTS:319995

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hindgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info