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    mes-1 Protein mes-1 [ Caenorhabditis elegans ]

    Gene ID: 181362, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mes-1
    Official Full Name
    Protein mes-1
    Primary source
    WormBase:WBGene00003219
    Locus tag
    CELE_F54F7.5
    See related
    AllianceGenome:WB:WBGene00003219
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tyrosine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; establishment of mitotic spindle localization; and left/right axis specification. Located in plasma membrane. Is expressed in E; Psub2; Psub3; Psub4; and germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mes-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (11857478..11862373)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene MX region of TRA-2 Related Neighboring gene Ovule protein Neighboring gene Elongin-C Neighboring gene Conserved plasma membrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans. Strome S, et al. Development, 1995 Sep. PMID 7555722
    2. Differences in maternal supply and early development of closely related nematode species. Laugsch M, et al. Int J Dev Biol, 2004 Sep. PMID 15470638
    3. Segregation of germ granules in living Caenorhabditis elegans embryos: cell-type-specific mechanisms for cytoplasmic localisation. Hird SN, et al. Development, 1996 Apr. PMID 8620857
    4. Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans. Kreher J, et al. Genetics, 2018 Nov. PMID 30217796, Free PMC Article
    5. Positioning of polarity formation by extracellular signaling during asymmetric cell division. Seirin Lee S. J Theor Biol, 2016 Jul 7. PMID 27086039

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the roles in epigenetic inheritance of MES-4 and MET-1
      Title: Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in Caenorhabditis elegans.
    2. mes-1 encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germ line and has a role in P. aeruginosa-induced neurodegeneration
      Title: Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans.
    3. Data show that the asymmetry of GPR-1/2 (which act with GOA-1 and GPA-16) localization depends on PAR-3 and its downstream intermediate LET-99, as well as on the MES-1/SRC-1 signaling pathway.
      Title: LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asymmetric protein localization involved in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in developmental process involved in reproduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic digestive tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in left/right axis specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein mes-1
    NP_741906.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11857478..11862373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171780.8 → NP_741906.1  Protein mes-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBL2
      Conserved Domains (1) summary
      cl21453
      Location:815 → 954
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBL2.1

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