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    rgs-1 RGS domain-containing protein;Regulator of G-protein signaling rgs-1 [ Caenorhabditis elegans ]

    Gene ID: 176415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgs-1
    Official Full Name
    RGS domain-containing protein;Regulator of G-protein signaling rgs-1
    Primary source
    WormBase:WBGene00004344
    Locus tag
    CELE_C05B5.7
    See related
    AllianceGenome:WB:WBGene00004344
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activator activity. Involved in chemosensory behavior and sensory perception of bitter taste. Is expressed in several structures, including excretory cell; head; nervous system; tail; and vulval muscle. Orthologous to several human genes including RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rgs-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (10014188..10016558, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene XK-related protein Neighboring gene ncRNA Neighboring gene putative insulin-like peptide alpha-type 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulator of G protein signaling-1 modulates paraquat-induced oxidative stress and longevity via the insulin like signaling pathway in Caenorhabditis elegans. Wu M, et al. Toxicol Lett, 2017 May 5. PMID 28366735
    2. An N-terminal region of Caenorhabditis elegans RGS proteins EGL-10 and EAT-16 directs inhibition of G(alpha)o versus G(alpha)q signaling. Patikoglou GA, et al. J Biol Chem, 2002 Dec 6. PMID 12354761
    3. Genome-Wide Screen for Genes Involved in Caenorhabditis elegans Developmentally Timed Sleep. Huang H, et al. G3 (Bethesda), 2017 Sep 7. PMID 28743807, Free PMC Article
    4. The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity. Krzyzanowski MC, et al. PLoS Genet, 2013. PMID 23874221, Free PMC Article
    5. G-protein signaling: satisfying the basic necessities of life. Wilkie TM. Curr Biol, 2000 Nov 30. PMID 11114530

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of bitter taste IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of bitter taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RGS domain-containing protein;Regulator of G-protein signaling rgs-1
    NP_001255056.1
    • Confirmed by transcript evidence
    NP_001369842.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10014188..10016558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382973.1 → NP_001369842.1  Regulator of G-protein signaling rgs-1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34295, Q9NHP9
      Conserved Domains (1) summary
      cl02565
      Location:38 → 154
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_001268127.3 → NP_001255056.1  RGS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1MN65
      Conserved Domains (1) summary
      cl02565
      Location:38 → 154
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34295.3

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