eef-2 Elongation factor 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eef-2
Official Full Name: Elongation factor 2
Primary source: WormBase:WBGene00001167
Locus tag: CELE_F25H5.4
See related: AllianceGenome:WB:WBGene00001167
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Involved in defense response to Gram-negative bacterium and negative regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eef-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (9163577..9166810)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25H5.4 (e-PCR)
- UniSTS:309943

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Elongation factor 2

NP_001367294.1

Confirmed by transcript evidence

NP_001369996.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9163577..9166810

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383584.2 → NP_001369996.1 Elongation factor 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

G3MU53, O17837, P29691

Conserved Domains (1) summary

PTZ00416
Location:1 → 852

PTZ00416; elongation factor 2; Provisional
NM_001380979.1 → NP_001367294.1 Elongation factor 2 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

PTZ00416
Location:1 → 840

PTZ00416; elongation factor 2; Provisional