cdc-25.2 M-phase inducer phosphatase;M-phase inducer phosphatase cdc-25.2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cdc-25.2
Official Full Name: M-phase inducer phosphatase;M-phase inducer phosphatase cdc-25.2
Primary source: WormBase:WBGene00000387
Locus tag: CELE_F16B4.8
See related: AllianceGenome:WB:WBGene00000387
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein tyrosine phosphatase activity. Involved in epidermal cell division. Acts upstream of or within nematode male tail tip morphogenesis. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hypodermis; nervous system; oocyte; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; endometrial cancer; prostate cancer; and urinary bladder cancer. Orthologous to several human genes including CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cdc-25.2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (1567076..1585532)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDC-25.2 is essential for cell divisions in ray precursor cell lineages for proper male tail development
Title: cdc-25.2, a Caenorhabditis elegans ortholog of cdc25, is required for male tail morphogenesis.
Results show that LIN-23 physically interacts with both CDC-25.1 and CDC-25.2 and facilitates ubiquitination for timely regulation of their activities during the intestinal development.
Title: LIN-23, an E3 Ubiquitin Ligase Component, Is Required for the Repression of CDC-25.2 Activity during Intestinal Development in Caenorhabditis elegans.
timely regulation of CDC-25.2 activity is essential for the progression of specialized division cycles and development of the C. elegans intestine.
Title: CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS5-270 (e-PCR)
- UniSTS:242439

F16B4.8 (e-PCR)
- UniSTS:309791

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in epidermal cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nematode male tail tip morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G2/MI transition of meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: M-phase inducer phosphatase;M-phase inducer phosphatase cdc-25.2

NP_001300079.1

Confirmed by transcript evidence

NP_001300080.1

Confirmed by transcript evidence

NP_503446.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

1567076..1585532

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071045.6 → NP_503446.1 M-phase inducer phosphatase cdc-25.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503446.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44628

Conserved Domains (1) summary

cd01530
Location:223 → 341

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
NM_001313150.4 → NP_001300079.1 M-phase inducer phosphatase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AXQ4

Conserved Domains (1) summary

cd01530
Location:201 → 319

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
NM_001313151.3 → NP_001300080.1 M-phase inducer phosphatase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3ASE2

Conserved Domains (1) summary

cd01530
Location:116 → 234

Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...