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    ham-2 Zinc finger protein ham-2 [ Caenorhabditis elegans ]

    Gene ID: 180727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ham-2
    Official Full Name
    Zinc finger protein ham-2
    Primary source
    WormBase:WBGene00001821
    Locus tag
    CELE_C07A12.1
    See related
    AllianceGenome:WB:WBGene00001821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in cell fate determination; cell migration; and regulation of neuron differentiation. Located in nucleus. Is expressed in head; hypodermis; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ham-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (4554685..4559408)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Ammonium transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SWI/SNF chromatin remodeling complex selectively affects multiple aspects of serotonergic neuron differentiation. Weinberg P, et al. Genetics, 2013 May. PMID 23457234, Free PMC Article
    2. The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron. Baum PD, et al. Genes Dev, 1999 Feb 15. PMID 10049362, Free PMC Article
    3. Asymmetric distribution of the C. elegans HAM-1 protein in neuroblasts enables daughter cells to adopt distinct fates. Guenther C, et al. Development, 1996 Nov. PMID 8951066
    4. Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Vavouri T, et al. Cell, 2009 Jul 10. PMID 19596244
    5. Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest. Kee Y, et al. Genes Dev, 2007 Feb 15. PMID 17322398, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc finger protein ham-2
    NP_001024363.2
    • Confirmed by transcript evidence
    NP_001024364.2
    • Confirmed by transcript evidence
    NP_001294827.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4554685..4559408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029193.7 → NP_001024364.2  Zinc finger protein ham-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024364.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3RMS1, A3RMS3, H2KYH4
      Conserved Domains (2) summary
      sd00017
      Location:18 → 39
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:16 → 39
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_001029192.7 → NP_001024363.2  Zinc finger protein ham-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024363.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3RMS1
      Conserved Domains (2) summary
      sd00017
      Location:18 → 39
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:16 → 39
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_001307898.3 → NP_001294827.1  Zinc finger protein ham-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A3RMS3
      Conserved Domains (1) summary
      sd00019
      Location:13 → 30
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H2KYH4.1

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