hipr-1 Huntington interacting protein related 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hipr-1
Official Full Name: Huntington interacting protein related 1
Primary source: WormBase:WBGene00022717
Locus tag: CELE_ZK370.3
See related: AllianceGenome:WB:WBGene00022717
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable several functions, including anion binding activity; clathrin adaptor activity; and clathrin light chain binding activity. Involved in several processes, including defecation; neurotransmitter secretion; and ultradian rhythm. Predicted to be located in cytoplasm; cytoskeleton; and presynapse. Predicted to be active in clathrin-coated vesicle and cortical actin cytoskeleton. Is expressed in germ line; gonad; neurons; and pharynx. Orthologous to human HIP1 (huntingtin interacting protein 1) and HIP1R (huntingtin interacting protein 1 related). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hipr-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 10

Sequence:: Chromosome: III; NC_003281.10 (8720202..8725333)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIP1 is involved in presynaptic nerve terminal activity and modulation of mutant polyglutamine-induced neuronal dysfunction. (HIP1; huntingtin-interacting protein 1; hipr1)
Title: Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK370.3 (e-PCR)
- UniSTS:310475

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IEA Inferred from Electronic Annotation more info
enables clathrin light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin coat assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in defecation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ultradian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Huntington interacting protein related 1

NP_001379566.1

Confirmed by transcript evidence

NP_741253.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

8720202..8725333

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392161.1 → NP_001379566.1 Huntington interacting protein related 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

smart00307
Location:716 → 914

ILWEQ; I/LWEQ domain

TIGR02168
Location:311 → 544

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam07651
Location:14 → 281

ANTH; ANTH domain
NM_171215.8 → NP_741253.1 Huntington interacting protein related 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741253.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02328, Q95PX2

Conserved Domains (3) summary

smart00307
Location:716 → 914

ILWEQ; I/LWEQ domain

pfam07651
Location:13 → 284

ANTH; ANTH domain

cl01629
Location:680 → 718

TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...