pars-2 Anticodon-binding domain-containing protein;Proline--tRNA ligase;proline--tRNA ligase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pars-2
Official Full Name: Anticodon-binding domain-containing protein;Proline--tRNA ligase;proline--tRNA ligase
Primary source: WormBase:WBGene00004190
Locus tag: CELE_T27F6.5
See related: AllianceGenome:WB:WBGene00004190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including body wall musculature; hermaphrodite distal tip cell; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 75. Orthologous to human PARS2 (prolyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pars-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (12486944..12490890)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T27F6.5 (e-PCR)
- UniSTS:315123

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables proline-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline-tRNA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in prolyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in prolyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Anticodon-binding domain-containing protein;Proline--tRNA ligase;proline--tRNA ligase

NP_001040689.1

Confirmed by transcript evidence

NP_001040690.1

Confirmed by transcript evidence

NP_001040691.1

Confirmed by transcript evidence

NP_001122525.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

12486944..12490890

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129053.4 → NP_001122525.1 Proline--tRNA ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122525.1

Status: REVIEWED

UniProtKB/TrEMBL

A5JYY0

Conserved Domains (1) summary

cl00268
Location:18 → 107

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
NM_001047224.6 → NP_001040689.1 proline--tRNA ligase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040689.1

Status: REVIEWED

UniProtKB/TrEMBL

O45869

Conserved Domains (2) summary

cd00779
Location:18 → 305

ProRS_core_prok; Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...

cd00861
Location:322 → 425

ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...
NM_001047226.3 → NP_001040691.1 Anticodon-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040691.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1ZXR9

Conserved Domains (2) summary

cd00861
Location:34 → 137

ProRS_anticodon_short; ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, ...

cl00268
Location:1 → 17

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
NM_001047225.3 → NP_001040690.1 Anticodon-binding domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040690.1

Status: REVIEWED

UniProtKB/TrEMBL

Q1ZXS0

Conserved Domains (1) summary

cl00266
Location:1 → 85

HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...