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    pix-1 SH3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181490, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pix-1
    Official Full Name
    SH3 domain-containing protein
    Primary source
    WormBase:WBGene00010776
    Locus tag
    CELE_K11E4.4
    See related
    AllianceGenome:WB:WBGene00010776
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in gonad morphogenesis; inductive cell migration; and neuron migration. Located in several cellular components, including adherens junction; cell periphery; and hemidesmosome. Is expressed in hermaphrodite gonad; hypodermis; and somatic gonad precursor. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to several human genes including ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pix-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (13727293..13734407)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene PON (paraoxonase) and MEC-6 Like Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-71 Neighboring gene Association with the SNF1 complex (ASC) domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells. Moody JC, et al. Nat Commun, 2020 Oct 6. PMID 33024114, Free PMC Article
    2. Distinct roles of Rac GTPases and the UNC-73/Trio and PIX-1 Rac GTP exchange factors in neuroblast protrusion and migration in C. elegans. Dyer JO, et al. Small GTPases, 2010 Jul. PMID 21686119, Free PMC Article
    3. The RhoGAP RRC-1 is required for the assembly or stability of integrin adhesion complexes and is a member of the PIX pathway in muscle. Moody JC, et al. Mol Biol Cell, 2024 Apr 1. PMID 38446619, Free PMC Article
    4. Rac1/RhoA antagonism defines cell-to-cell heterogeneity during epidermal morphogenesis in nematodes. Martin E, et al. J Cell Biol, 2016 Nov 21. PMID 27821782, Free PMC Article
    5. A tension-induced mechanotransduction pathway promotes epithelial morphogenesis. Zhang H, et al. Nature, 2011 Mar 3. PMID 21368832

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.
      Title: The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.
    2. pix-1 has a role in controlling early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans
      Title: pix-1 controls early elongation in parallel with mel-11 and let-502 in Caenorhabditis elegans.
    3. only PAK-1 functions in the GIT/PIX/PAK pathway independently of RAC/CDC42 GTPases
      Title: A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in gonad morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inductive cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SH3 domain-containing protein
    NP_001257227.1
    • Confirmed by transcript evidence
    NP_001257228.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13727293..13734407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270298.4 → NP_001257227.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21430
      Conserved Domains (3) summary
      cd11877
      Location:11 → 62
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:93 → 261
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16523
      Location:554 → 637
      betaPIX_CC; betaPIX coiled coil

    2. NM_001270299.3 → NP_001257228.1  SH3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257228.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3W735
      Conserved Domains (2) summary
      cd11877
      Location:11 → 62
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:93 → 261
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    Nucleotide Protein
    Heading Accession and Version

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