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    ect-2 Protein ECT2 [ Caenorhabditis elegans ]

    Gene ID: 174658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ect-2
    Official Full Name
    Protein ECT2
    Primary source
    WormBase:WBGene00002297
    Locus tag
    CELE_T19E10.1
    See related
    AllianceGenome:WB:WBGene00002297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; mitotic cytokinesis; and regulation of actin filament-based process. Located in cell cortex. Is expressed in several structures, including P3.p hermaphrodite; germ line; hermaphrodite gonad; neuroblasts; and somatic gonad precursor. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ect-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    15
    Sequence:
    Chromosome: II; NC_003280.10 (10778389..10783293, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing protein C52A11.3 Neighboring gene PDZ domain-containing protein Neighboring gene ncRNA Neighboring gene Histone RNA hairpin-binding protein Neighboring gene Putative protein tag-209

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An interphase contractile ring reshapes primordial germ cells to allow bulk cytoplasmic remodeling. Maniscalco C, et al. J Cell Biol, 2020 Feb 3. PMID 31819975, Free PMC Article
    2. The RhoGAP domain of CYK-4 has an essential role in RhoA activation. Loria A, et al. Curr Biol, 2012 Feb 7. PMID 22226748, Free PMC Article
    3. A GAP that Divides. Basant A, et al. F1000Res, 2017. PMID 29043078, Free PMC Article
    4. CYK-4 regulates Rac, but not Rho, during cytokinesis. Zhuravlev Y, et al. Mol Biol Cell, 2017 May 1. PMID 28298491, Free PMC Article
    5. Cytokinesis: progress on all fronts. Glotzer M. Curr Opin Cell Biol, 2003 Dec. PMID 14644192

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An interphase contractile ring reshapes primordial germ cells to allow bulk cytoplasmic remodeling.
      Title: An interphase contractile ring reshapes primordial germ cells to allow bulk cytoplasmic remodeling.
    2. a Rho GEF, ECT-2, acts downstream of AIR-1 in regulating contractility and PAR-2 localisation, and AIR-1 depletion influences ECT-2 cortical localisation
      Title: Centrosome Aurora A regulates RhoGEF ECT-2 localisation and ensures a single PAR-2 polarity axis in C. elegans embryos.
    3. Polarity in the C. elegans zygote is initiated by redundant ECT-2- and PAR-2-dependent mechanisms that lower PAR-3 levels locally, triggering a positive-feedback loop that polarizes the entire cortex.
      Title: Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric protein localization involved in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin filament-based process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis, actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein ECT2
    NP_496318.1
    • Confirmed by transcript evidence
    NP_496319.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10778389..10783293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063917.6 → NP_496318.1  Protein ECT2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496318.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U364
      Conserved Domains (4) summary
      smart00292
      Location:209 → 280
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:131 → 188
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam00621
      Location:367 → 560
      RhoGEF; RhoGEF domain
      cl17171
      Location:551 → 729
      PH-like; Pleckstrin homology-like domain

    2. NM_063918.4 → NP_496319.1  Protein ECT2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22590
      Conserved Domains (4) summary
      smart00292
      Location:209 → 280
      BRCT; breast cancer carboxy-terminal domain
      cd00027
      Location:131 → 188
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam00621
      Location:367 → 560
      RhoGEF; RhoGEF domain
      cl17171
      Location:551 → 729
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version

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