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    alx-1 Apoptosis-linked gene 2-interacting protein X 1 [ Caenorhabditis elegans ]

    Gene ID: 176410, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alx-1
    Official Full Name
    Apoptosis-linked gene 2-interacting protein X 1
    Primary source
    WormBase:WBGene00007010
    Locus tag
    CELE_R10E12.1
    See related
    AllianceGenome:WB:WBGene00007010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables Notch binding activity. Involved in several processes, including endocytic recycling; endosome organization; and regulation of protein catabolic process. Located in basolateral plasma membrane; multivesicular body; and recycling endosome. Is expressed in several structures, including vulva. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human PDCD6IP (programmed cell death 6 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See alx-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (9957351..9963131)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a putative element in signal transduction. Che S, et al. Biochim Biophys Acta, 1997 Nov 20. PMID 9427532
    2. LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans. Shaye DD, et al. Development, 2005 Nov. PMID 16236769
    3. A novel requirement for C. elegans Alix/ALX-1 in RME-1-mediated membrane transport. Shi A, et al. Curr Biol, 2007 Nov 20. PMID 17997305, Free PMC Article
    4. The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans. Liu Y, et al. Genetics, 2007 Aug. PMID 17603118, Free PMC Article
    5. ESCRT-Dependent Cell Death in a Caenorhabditis elegans Model of the Lysosomal Storage Disorder Mucolipidosis Type IV. Huynh JM, et al. Genetics, 2016 Feb. PMID 26596346, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interacts with RME-1, required for endocytic recyling pathway.
      Title: A novel requirement for C. elegans Alix/ALX-1 in RME-1-mediated membrane transport.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Apoptosis-linked gene 2-interacting protein X 1
    NP_001022713.1
    • Confirmed by transcript evidence
    NP_001022714.1
    • Confirmed by transcript evidence
    NP_001022715.1
    • Confirmed by transcript evidence
    NP_499213.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9957351..9963131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027543.4 → NP_001022714.1  Apoptosis-linked gene 2-interacting protein X 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022714.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34552
      Conserved Domains (3) summary
      cd09235
      Location:366 → 704
      V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
      cd09240
      Location:4 → 351
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
      pfam13949
      Location:419 → 707
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

    2. NM_066812.8 → NP_499213.1  Apoptosis-linked gene 2-interacting protein X 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499213.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34552
      Conserved Domains (3) summary
      cd09235
      Location:366 → 704
      V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
      cd09240
      Location:4 → 351
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
      pfam13949
      Location:419 → 707
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

    3. NM_001027542.5 → NP_001022713.1  Apoptosis-linked gene 2-interacting protein X 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022713.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34552, Q7YXC7, Q8I114, Q8I115, Q94159
      Conserved Domains (3) summary
      cd09235
      Location:366 → 704
      V_Alix; Middle V-domain of mammalian Alix and related domains are dimerization and protein interaction modules
      cd09240
      Location:4 → 351
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
      pfam13949
      Location:419 → 707
      ALIX_LYPXL_bnd; ALIX V-shaped domain binding to HIV

    4. NM_001027544.3 → NP_001022715.1  Apoptosis-linked gene 2-interacting protein X 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022715.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34552
      Conserved Domains (1) summary
      cd09240
      Location:4 → 351
      BRO1_Alix; Protein-interacting, N-terminal, Bro1-like domain of mammalian Alix and related domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34552.3

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