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    Y22D7AL.10 10 kDa heat shock protein, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 175315, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y22D7AL.10
    Official Full Name
    10 kDa heat shock protein, mitochondrial
    Primary source
    WormBase:WBGene00021248
    Locus tag
    CELE_Y22D7AL.10
    See related
    AllianceGenome:WB:WBGene00021248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be active in mitochondrial matrix. Orthologous to human HSPE1 (heat shock protein family E (Hsp10) member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y22D7AL.10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (1617151..1618929, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene DUF5675 domain-containing protein Neighboring gene Tetratricopeptide repeat protein 7B Neighboring gene Chaperonin homolog Hsp-60, mitochondrial;Heat shock protein 60 Neighboring gene Transcription initiation factor TFIID subunit 7 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling. Jeong DE, et al. EMBO J, 2017 Apr 13. PMID 28283579, Free PMC Article
    2. Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Duchaine TF, et al. Cell, 2006 Jan 27. PMID 16439208
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    10 kDa heat shock protein, mitochondrial
    NP_497428.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1617151..1618929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065027.9 → NP_497428.1  10 kDa heat shock protein, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497428.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q965Q1
      Conserved Domains (1) summary
      smart00883
      Location:15 → 107
      Cpn10; Chaperonin 10 Kd subunit
    Nucleotide Protein
    Heading Accession and Version

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