CDC20B cell division cycle 20B [Homo sapiens (human)] - Gene

Summary

Official Symbol: CDC20Bprovided by HGNC
Official Full Name: cell division cycle 20Bprovided by HGNC
Primary source: HGNC:HGNC:24222
See related: Ensembl:ENSG00000164287 MIM:620335; AllianceGenome:HGNC:24222
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: G6VTS76519
Summary: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in de novo centriole assembly. Located in deuterosome. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 5q11.2

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (55112971..55173177, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (55940297..56000463, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (54408799..54469005, complement)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis.
Title: Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis.
CDC20B protein associates to deuterosomes and is required for centriole release and subsequent cilia production.
Title: CDC20B is required for deuterosome-mediated centriole production in multiciliated cells.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

STS-N33071 (e-PCR)
- UniSTS:30486

D18S21 (e-PCR)
- UniSTS:148514

STS-N22158 (e-PCR)
- UniSTS:68960

PMC152543P1 (e-PCR)
- UniSTS:271225

SGC34842 (e-PCR)
- UniSTS:54463

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in de novo centriole assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in deuterosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cell division cycle protein 20 homolog B

Names: CDC20 cell division cycle 20 homolog B; CDC20-like protein; cell division cycle 20 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145734.2 → NP_001139206.2 cell division cycle protein 20 homolog B isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 3. This variant encodes isoform 2, which is shorter than isoform 3.

Source sequence(s)

AB086378, AC091977, AK095246, DB237622

Consensus CDS

CCDS47207.1

UniProtKB/Swiss-Prot

Q86Y33

Related

ENSP00000315720.6, ENST00000322374.10

Conserved Domains (3) summary

COG2319
Location:183 → 476

WD40; WD40 repeat [General function prediction only]

sd00039
Location:277 → 313

7WD40; WD40 repeat [structural motif]

cl02567
Location:236 → 475

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001170402.1 → NP_001163873.1 cell division cycle protein 20 homolog B isoform 3

See identical proteins and their annotated locations for NP_001163873.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AC091977, AK095246, BC136572, DB237622

Consensus CDS

CCDS54852.1

UniProtKB/Swiss-Prot

B7WNV8, B9EGL8, C9J6X8, C9JHE9, C9JKL5, Q86Y31, Q86Y32, Q86Y33, Q8IUZ8, Q8N1S1, Q8NG56

Related

ENSP00000370781.2, ENST00000381375.7

Conserved Domains (3) summary

COG2319
Location:230 → 518

WD40; WD40 repeat [General function prediction only]

sd00039
Location:276 → 313

7WD40; WD40 repeat [structural motif]

cl02567
Location:276 → 517

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_152623.2 → NP_689836.2 cell division cycle protein 20 homolog B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform 1), compared to isoform 3.

Source sequence(s)

AC091977, AI471861, AK095246, DB237622

Consensus CDS

CCDS3966.1

UniProtKB/Swiss-Prot

Q86Y33

Related

ENSP00000296733.1, ENST00000296733.5

Conserved Domains (3) summary

COG2319
Location:230 → 514

WD40; WD40 repeat [General function prediction only]

sd00039
Location:276 → 313

7WD40; WD40 repeat [structural motif]

cl02567
Location:276 → 513

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...