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    FES FES proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 2242, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FESprovided by HGNC
    Official Full Name
    FES proto-oncogene, tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:3657
    See related
    Ensembl:ENSG00000182511 MIM:190030; AllianceGenome:HGNC:3657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FPS
    Summary
    This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]
    Expression
    Broad expression in spleen (RPKM 39.1), bone marrow (RPKM 25.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FES in Genome Data Viewer
    Location:
    15q26.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (90884504..90895776)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (88643915..88655365)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91427734..91439006)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 363, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:91412350-91413549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10096 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10097 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6830 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10101 Neighboring gene mannosidase alpha class 2A member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10103 Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Confirmation of 15q26.1 as the site of the FES protooncogene by fluorescence in situ hybridization. Mathew S, et al. Cytogenet Cell Genet, 1993. PMID 8449035
    2. A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer. Delfino FJ, et al. J Biol Chem, 2006 Mar 31. PMID 16455651
    3. Solution structure of the Src homology 2 domain from the human feline sarcoma oncogene Fes. Scott A, et al. J Biomol NMR, 2005 Apr. PMID 15929003
    4. NMR assignment of the SH2 domain from the human feline sarcoma oncogene FES. Scott A, et al. J Biomol NMR, 2004 Dec. PMID 15630569
    5. Vascular defects in gain-of-function fps/fes transgenic mice correlate with PDGF- and VEGF-induced activation of mutant Fps/Fes kinase in endothelial cells. Sangrar W, et al. J Thromb Haemost, 2004 May. PMID 15099290

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
      Title: The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis.
    2. Identification of FES as a Novel Radiosensitizing Target in Human Cancers.
      Title: Identification of FES as a Novel Radiosensitizing Target in Human Cancers.
    3. This study supports the critical role of FER and FES tyrosine kinase fusions in the pathogenesis of follicular T-cell lymphoma and provides additional evidence that these can drive follicular T-cell lymphoma in the absence of RHOA mutations.
      Title: FER and FES tyrosine kinase fusions in follicular T-cell lymphoma.
    4. analysis of the JAK-Fes-phospholipase D signaling pathway that is enhanced in highly proliferative breast cancer cells
      Title: A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.
    5. c-fes gene expression was found in myeloid leukemias, whereas low or no expression in lymphocytic leukemias.
      Title: [Expression of c-fes gene in leukemia cells and its clinical significance].
    6. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    7. FES kinase is a mediator of wild-type KIT signalling implicated in cell migration.
      Title: FES kinase participates in KIT-ligand induced chemotaxis.
    8. FGF-2 activates Fes via the second coiled-coil domain, leading to lamellipodium formation and chemotaxis by endothelial cells
      Title: Inhibition of endothelial cell chemotaxis toward FGF-2 by gefitinib associates with downregulation of Fes activity.
    9. c-Fes oligomerization is independent of activation; data suggest that conformational changes, rather than oligomerization, govern c-Fes kinase activation and downstream signaling in vivo.
      Title: Bimolecular fluorescence complementation demonstrates that the c-Fes protein-tyrosine kinase forms constitutive oligomers in living cells.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables immunoglobulin receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to vitamin D IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule bundle formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mast cell degranulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase Fes/Fps
    Names
    Oncogene FES, feline sarcoma virus
    feline sarcoma (Snyder-Theilen) viral (v-fes)/Fujinami avian sarcoma (PRCII) viral (v-fps) oncogene homolog
    feline sarcoma oncogene
    feline sarcoma/Fujinami avian sarcoma oncogene homolog
    p93c-fes
    proto-oncogene c-Fes
    proto-oncogene c-Fps
    proto-oncogene tyrosine-protein kinase Fes/Fps
    NP_001137255.1
    NP_001137256.1
    NP_001137257.1
    NP_001996.1
    XP_005254937.1
    XP_005254939.1
    XP_016877494.1
    XP_016877495.1
    XP_016877496.1
    XP_016877497.1
    XP_016877498.1
    XP_016877499.1
    XP_047288189.1
    XP_047288190.1
    XP_047288191.1
    XP_047288192.1
    XP_047288193.1
    XP_047288194.1
    XP_047288195.1
    XP_054233470.1
    XP_054233471.1
    XP_054233472.1
    XP_054233473.1
    XP_054233474.1
    XP_054233475.1
    XP_054233476.1
    XP_054233477.1
    XP_054233478.1
    XP_054233479.1
    XP_054233480.1
    XP_054233481.1
    XP_054233482.1
    XP_054233483.1
    XP_054233484.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029671.1 RefSeqGene

      Range
      5047..16319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001143783.1 → NP_001137255.1  tyrosine-protein kinase Fes/Fps isoform 2

      See identical proteins and their annotated locations for NP_001137255.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1, and encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513656
      Consensus CDS
      CCDS45350.1
      UniProtKB/TrEMBL
      B4DUD9
      Related
      ENSP00000377837.3, ENST00000394300.7
      Conserved Domains (4) summary
      cd10361
      Location:395 → 479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506 → 757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503 → 756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    2. NM_001143784.1 → NP_001137256.1  tyrosine-protein kinase Fes/Fps isoform 3

      See identical proteins and their annotated locations for NP_001137256.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, and encodes a protein (isoform 3) with a shorter C-terminus and an incomplete SH2 domain, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513657
      Consensus CDS
      CCDS45349.1
      UniProtKB/TrEMBL
      B4DUD9
      Related
      ENSP00000400868.2, ENST00000444422.2
      Conserved Domains (3) summary
      cd05084
      Location:494 → 745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491 → 744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    3. NM_001143785.2 → NP_001137257.1  tyrosine-protein kinase Fes/Fps isoform 4

      See identical proteins and their annotated locations for NP_001137257.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks multiple in-frame exons in the coding region, compared to variant 1, and encodes a shorter protein (isoform 4) with an incomplete SH2 domain, compared to isoform 1.
      Source sequence(s)
      AC124248, AY513654, DB264752
      Consensus CDS
      CCDS45351.1
      UniProtKB/TrEMBL
      E7ENM8
      Related
      ENSP00000414629.2, ENST00000414248.6
      Conserved Domains (3) summary
      cd05084
      Location:436 → 687
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:433 → 686
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. NM_002005.4 → NP_001996.1  tyrosine-protein kinase Fes/Fps isoform 1

      See identical proteins and their annotated locations for NP_001996.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC124248, X52192
      Consensus CDS
      CCDS10365.1
      UniProtKB/Swiss-Prot
      B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
      UniProtKB/TrEMBL
      B4DUD9
      Related
      ENSP00000331504.3, ENST00000328850.8
      Conserved Domains (4) summary
      cd07685
      Location:7 → 239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453 → 537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564 → 815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561 → 814
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      90884504..90895776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022009.3 → XP_016877498.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
      UniProtKB/TrEMBL
      B4DUD9
      Conserved Domains (4) summary
      cd07685
      Location:7 → 239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453 → 537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564 → 815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561 → 814
      Pkinase_Tyr; Protein tyrosine kinase

    2. XM_047432235.1 → XP_047288191.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/TrEMBL
      B4DUD9

    3. XM_017022010.2 → XP_016877499.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      B4DUD9
      Conserved Domains (4) summary
      cd10361
      Location:395 → 479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506 → 757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503 → 756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    4. XM_047432237.1 → XP_047288193.1  tyrosine-protein kinase Fes/Fps isoform X4

      UniProtKB/TrEMBL
      E7ENM8

    5. XM_047432233.1 → XP_047288189.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
      UniProtKB/TrEMBL
      B4DUD9

    6. XM_047432234.1 → XP_047288190.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      B4DUD9

    7. XM_005254882.3 → XP_005254939.1  tyrosine-protein kinase Fes/Fps isoform X3

      See identical proteins and their annotated locations for XP_005254939.1

      UniProtKB/TrEMBL
      B4DUD9
      Conserved Domains (3) summary
      cd05084
      Location:494 → 745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491 → 744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    8. XM_005254880.2 → XP_005254937.1  tyrosine-protein kinase Fes/Fps isoform X2

      See identical proteins and their annotated locations for XP_005254937.1

      UniProtKB/TrEMBL
      B4DUD9
      Conserved Domains (4) summary
      cd10361
      Location:395 → 479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506 → 757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503 → 756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    9. XM_017022005.2 → XP_016877494.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
      UniProtKB/TrEMBL
      B4DUD9
      Conserved Domains (4) summary
      cd07685
      Location:7 → 239
      F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
      cd10361
      Location:453 → 537
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:564 → 815
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:561 → 814
      Pkinase_Tyr; Protein tyrosine kinase

    10. XM_017022007.2 → XP_016877496.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/TrEMBL
      B4DUD9
      Conserved Domains (3) summary
      cd05084
      Location:494 → 745
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:491 → 744
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 239
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    11. XM_017022006.2 → XP_016877495.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      B4DUD9
      Conserved Domains (4) summary
      cd10361
      Location:395 → 479
      SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
      cd05084
      Location:506 → 757
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:503 → 756
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    12. XM_017022008.2 → XP_016877497.1  tyrosine-protein kinase Fes/Fps isoform X4

      UniProtKB/TrEMBL
      E7ENM8
      Conserved Domains (3) summary
      cd05084
      Location:436 → 687
      PTKc_Fes; Catalytic domain of the Protein Tyrosine Kinase, Fes
      pfam07714
      Location:433 → 686
      Pkinase_Tyr; Protein tyrosine kinase
      cl12013
      Location:7 → 181
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    13. XM_047432239.1 → XP_047288195.1  tyrosine-protein kinase Fes/Fps isoform X5

      Related
      ENSP00000435811.1, ENST00000464684.5

    14. XM_047432236.1 → XP_047288192.1  tyrosine-protein kinase Fes/Fps isoform X5

    15. XM_047432238.1 → XP_047288194.1  tyrosine-protein kinase Fes/Fps isoform X6

      UniProtKB/TrEMBL
      E9PIJ7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      88643915..88655365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377499.1 → XP_054233474.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
      UniProtKB/TrEMBL
      B4DUD9

    2. XM_054377507.1 → XP_054233482.1  tyrosine-protein kinase Fes/Fps isoform X4

      UniProtKB/TrEMBL
      E7ENM8

    3. XM_054377505.1 → XP_054233480.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/TrEMBL
      B4DUD9

    4. XM_054377502.1 → XP_054233477.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      B4DUD9

    5. XM_054377503.1 → XP_054233478.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      B4DUD9

    6. XM_054377500.1 → XP_054233475.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
      UniProtKB/TrEMBL
      B4DUD9

    7. XM_054377504.1 → XP_054233479.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/TrEMBL
      B4DUD9

    8. XM_054377501.1 → XP_054233476.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      B4DUD9

    9. XM_054377495.1 → XP_054233470.1  tyrosine-protein kinase Fes/Fps isoform X1

      UniProtKB/Swiss-Prot
      B2R6E6, B4DUD0, E9PC94, E9PC95, P07332, Q2VXS7, Q2VXS8, Q2VXT0, Q6GTU5
      UniProtKB/TrEMBL
      B4DUD9

    10. XM_054377497.1 → XP_054233472.1  tyrosine-protein kinase Fes/Fps isoform X3

      UniProtKB/TrEMBL
      B4DUD9

    11. XM_054377496.1 → XP_054233471.1  tyrosine-protein kinase Fes/Fps isoform X2

      UniProtKB/TrEMBL
      B4DUD9

    12. XM_054377498.1 → XP_054233473.1  tyrosine-protein kinase Fes/Fps isoform X4

      UniProtKB/TrEMBL
      E7ENM8

    13. XM_054377509.1 → XP_054233484.1  tyrosine-protein kinase Fes/Fps isoform X5

    14. XM_054377506.1 → XP_054233481.1  tyrosine-protein kinase Fes/Fps isoform X5

    15. XM_054377508.1 → XP_054233483.1  tyrosine-protein kinase Fes/Fps isoform X6

      UniProtKB/TrEMBL
      E9PIJ7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07332.3 GenPept UniProtKB/Swiss-Prot:P07332

    Gene LinkOut

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