Frmd3 FERM domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Frmd3provided by MGI
Official Full Name: FERM domain containing 3provided by MGI
Primary source: MGI:MGI:2442466
See related: Ensembl:ENSMUSG00000049122 AllianceGenome:MGI:2442466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4.1O; P410; EPB41L4O; 9430066I12Rik
Summary: Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in membrane. Predicted to be active in cytoskeleton. Orthologous to human FRMD3 (FERM domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 3.9), whole brain E14.5 (RPKM 2.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C3; 4 36.06 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (73931454..74120451)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (74013228..74202214)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tumor suppressor FRMD3 controls mammary epithelial cell fate determination via notch signaling pathway.
Title: Tumor suppressor FRMD3 controls mammary epithelial cell fate determination via notch signaling pathway.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FERM domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163732.1 → NP_001157204.1 FERM domain-containing protein 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different exon for its 3' terminus, compared to variant 1, which results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK034956, AK079349

Consensus CDS

CCDS51212.1

UniProtKB/Swiss-Prot

Q8BHD4

UniProtKB/TrEMBL

Q8BV94

Related

ENSMUSP00000095615.3, ENSMUST00000098006.9

Conserved Domains (5) summary

smart00295
Location:33 → 225

B41; Band 4.1 homologues

pfam00373
Location:117 → 225

FERM_M; FERM central domain

pfam08736
Location:323 → 357

FA; FERM adjacent (FA)

pfam09379
Location:36 → 99

FERM_N; FERM N-terminal domain

cl17171
Location:206 → 309

PH-like; Pleckstrin homology-like domain
NM_172869.5 → NP_766457.1 FERM domain-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_766457.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL844607, BX088570, BX957282

Consensus CDS

CCDS38789.1

UniProtKB/Swiss-Prot

A2BEJ6, Q3UF23, Q5SPU0, Q5SPU1, Q8BHD4, Q8C045

Related

ENSMUSP00000081514.6, ENSMUST00000084474.6

Conserved Domains (5) summary

smart00295
Location:33 → 225

B41; Band 4.1 homologues

pfam00373
Location:117 → 225

FERM_M; FERM central domain

pfam08736
Location:323 → 357

FA; FERM adjacent (FA)

pfam09379
Location:36 → 99

FERM_N; FERM N-terminal domain

cl17171
Location:206 → 309

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

73931454..74120451

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030253548.2 → XP_030109408.1 FERM domain-containing protein 3 isoform X1

Conserved Domains (2) summary

pfam08736
Location:74 → 119

FA; FERM adjacent (FA)

cl17171
Location:11 → 60

PH-like; Pleckstrin homology-like domain