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    Taok1 TAO kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 216965, updated on 9-Dec-2024

    Summary

    Official Symbol
    Taok1provided by MGI
    Official Full Name
    TAO kinase 1provided by MGI
    Primary source
    MGI:MGI:1914490
    See related
    Ensembl:ENSMUSG00000017291 AllianceGenome:MGI:1914490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Psk2; Markk; Map3k16; 2810468K05Rik; D130018F14Rik
    Summary
    Predicted to enable several functions, including cytoskeletal protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in central nervous system neuron development. Predicted to be located in microtubule cytoskeleton and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including adrenal gland; alimentary system; lung; nervous system; and submandibular gland primordium. Orthologous to human TAOK1 (TAO kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.8), frontal lobe adult (RPKM 7.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Taok1 in Genome Data Viewer
    Location:
    11 B5; 11 46.64 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (77419988..77516185, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (77529162..77625359, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene predicted gene 10392 Neighboring gene abhydrolase domain containing 15 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8973 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 23132

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC29021, mKIAA1361

    Gene Ontology Provided by MGI

    Items 1 - 25 of 35
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables alpha-tubulin binding  
    enables alpha-tubulin binding  
    enables beta-tubulin binding  
    enables beta-tubulin binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables kinase activity  
    enables myosin V binding  
    enables protein kinase activator activity  
    enables protein kinase activity  
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activator activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 35
    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA repair  
    involved_in central nervous system neuron development PubMed 
    involved_in central nervous system neuron development  
    involved_in chromatin remodeling  
    involved_in execution phase of apoptosis  
    involved_in execution phase of apoptosis  
    involved_in microtubule cytoskeleton organization  
    involved_in microtubule cytoskeleton organization  
    involved_in mitotic G2 DNA damage checkpoint signaling  
    involved_in mitotic G2 DNA damage checkpoint signaling  
    involved_in negative regulation of microtubule depolymerization  
    involved_in negative regulation of microtubule depolymerization  
    involved_in neuron cellular homeostasis  
    involved_in neuron cellular homeostasis  
    involved_in phosphorylation  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of JNK cascade  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in positive regulation of stress-activated MAPK cascade  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of cytoskeleton organization  
    involved_in regulation of cytoskeleton organization  
    involved_in regulation of cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    serine/threonine-protein kinase TAO1
    Names
    serine/threonine protein kinase TAO1 homolog
    thousand and one amino acid protein 1
    NP_001351062.1
    NP_001351063.1
    NP_659074.2
    XP_006533022.1
    XP_006533023.1
    XP_011247232.1
    XP_030101697.1
    XP_036012472.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364133.1NP_001351062.1  serine/threonine-protein kinase TAO1

      Status: VALIDATED

      Source sequence(s)
      AL591136
      Consensus CDS
      CCDS36235.1
      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    2. NM_001364134.1NP_001351063.1  serine/threonine-protein kinase TAO1

      Status: VALIDATED

      Source sequence(s)
      AL591136
      Consensus CDS
      CCDS36235.1
      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    3. NM_144825.3NP_659074.2  serine/threonine-protein kinase TAO1

      See identical proteins and their annotated locations for NP_659074.2

      Status: VALIDATED

      Source sequence(s)
      AK013386, AK143530, AK173156, BC034906, BE691513, CF164486, CN717576, CN717636, CN718413, CN721819, CN724017, CN724388
      Consensus CDS
      CCDS36235.1
      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Related
      ENSMUSP00000055470.8, ENSMUST00000058496.8
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      77419988..77516185 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245837.2XP_030101697.1  serine/threonine-protein kinase TAO1 isoform X1

      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Related
      ENSMUSP00000017435.5, ENSMUST00000017435.11
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    2. XM_011248930.4XP_011247232.1  serine/threonine-protein kinase TAO1 isoform X1

      See identical proteins and their annotated locations for XP_011247232.1

      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    3. XM_006532960.4XP_006533023.1  serine/threonine-protein kinase TAO1 isoform X2

      Conserved Domains (3) summary
      COG0419
      Location:194625
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl21453
      Location:1170
      PKc_like; Protein Kinases, catalytic domain
      cl27706
      Location:656713
      Prion; Prion/Doppel alpha-helical domain
    4. XM_006532959.5XP_006533022.1  serine/threonine-protein kinase TAO1 isoform X1

      See identical proteins and their annotated locations for XP_006533022.1

      UniProtKB/Swiss-Prot
      Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7
      UniProtKB/TrEMBL
      B2RX66
      Conserved Domains (2) summary
      COG0419
      Location:442877
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd06635
      Location:2318
      STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
    5. XM_036156579.1XP_036012472.1  serine/threonine-protein kinase TAO1 isoform X2

      Conserved Domains (3) summary
      COG0419
      Location:194625
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cl21453
      Location:1170
      PKc_like; Protein Kinases, catalytic domain
      cl27706
      Location:656713
      Prion; Prion/Doppel alpha-helical domain

    RNA

    1. XR_004936918.1 RNA Sequence

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