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    Togaram2 TOG array regulator of axonemal microtubules 2 [ Mus musculus (house mouse) ]

    Gene ID: 320159, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Togaram2provided by MGI
    Official Full Name
    TOG array regulator of axonemal microtubules 2provided by MGI
    Primary source
    MGI:MGI:2443498
    See related
    Ensembl:ENSMUSG00000045761 AllianceGenome:MGI:2443498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam179a; 4632412N22Rik
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in microtubule cytoskeleton. Predicted to be active in cilium and cytoplasmic microtubule. Orthologous to human TOGARAM2 (TOG array regulator of axonemal microtubules 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in lung adult (RPKM 5.5), ovary adult (RPKM 3.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Togaram2 in Genome Data Viewer
    Location:
    17 E1.3; 17 42.06 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (71980153..72036666)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71673156..71729671)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 43 Neighboring gene small nucleolar RNA, C/D box 53 Neighboring gene predicted gene, 22858 Neighboring gene STARR-positive B cell enhancer ABC_E10969 Neighboring gene photoreceptor cilium actin regulator Neighboring gene STARR-seq mESC enhancer starr_43179 Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene predicted gene, 30140

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TOG array regulator of axonemal microtubules protein 2
    Names
    crescerin-2
    family with sequence similarity 179, member A
    protein FAM179A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177087.4 → NP_796061.2  TOG array regulator of axonemal microtubules protein 2

      See identical proteins and their annotated locations for NP_796061.2

      Status: VALIDATED

      Source sequence(s)
      AK158647, BB868766
      Consensus CDS
      CCDS28961.2
      UniProtKB/Swiss-Prot
      Q3TYG6, Q8C7B2
      UniProtKB/TrEMBL
      F6YU21
      Related
      ENSMUSP00000094886.4, ENSMUST00000097284.10
      Conserved Domains (1) summary
      pfam12348
      Location:496 → 679
      CLASP_N; CLASP N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      71980153..72036666
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160646.1 → XP_036016539.1  TOG array regulator of axonemal microtubules protein 2 isoform X5

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (2) summary
      PHA03247
      Location:24 → 315
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:496 → 672
      CLASP_N; CLASP N terminal

    2. XM_006524399.5 → XP_006524462.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006524462.1

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (2) summary
      PHA03247
      Location:24 → 315
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:496 → 672
      CLASP_N; CLASP N terminal

    3. XM_006524396.4 → XP_006524459.2  TOG array regulator of axonemal microtubules protein 2 isoform X1

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (2) summary
      PHA03247
      Location:16 → 398
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:579 → 755
      CLASP_N; CLASP N terminal

    4. XM_006524406.5 → XP_006524469.1  TOG array regulator of axonemal microtubules protein 2 isoform X6

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (1) summary
      pfam12348
      Location:420 → 596
      CLASP_N; CLASP N terminal

    5. XM_006524397.5 → XP_006524460.2  TOG array regulator of axonemal microtubules protein 2 isoform X2

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (2) summary
      PHA03247
      Location:16 → 398
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:579 → 755
      CLASP_N; CLASP N terminal

    6. XM_006524403.5 → XP_006524466.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006524466.1

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (2) summary
      PHA03247
      Location:24 → 315
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:496 → 672
      CLASP_N; CLASP N terminal

    7. XM_006524398.5 → XP_006524461.1  TOG array regulator of axonemal microtubules protein 2 isoform X3

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (2) summary
      PHA03247
      Location:83 → 374
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:555 → 731
      CLASP_N; CLASP N terminal

    8. XM_006524400.5 → XP_006524463.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006524463.1

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (2) summary
      PHA03247
      Location:24 → 315
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:496 → 672
      CLASP_N; CLASP N terminal

    9. XM_006524402.5 → XP_006524465.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006524465.1

      UniProtKB/TrEMBL
      F6YU21
      Conserved Domains (2) summary
      PHA03247
      Location:24 → 315
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:496 → 672
      CLASP_N; CLASP N terminal

    10. XM_006524401.4 → XP_006524464.1  TOG array regulator of axonemal microtubules protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006524464.1

      UniProtKB/TrEMBL
      F6YU21
      Related
      ENSMUSP00000114359.2, ENSMUST00000144479.2
      Conserved Domains (2) summary
      PHA03247
      Location:24 → 315
      PHA03247; large tegument protein UL36; Provisional
      pfam12348
      Location:496 → 672
      CLASP_N; CLASP N terminal

    11. XM_036160647.1 → XP_036016540.1  TOG array regulator of axonemal microtubules protein 2 isoform X7

      Conserved Domains (1) summary
      pfam12348
      Location:136 → 312
      CLASP_N; CLASP N terminal

    RNA

    1. XR_004939537.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TYG6.1 GenPept UniProtKB/Swiss-Prot:Q3TYG6

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