Fignl2 fidgetin-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fignl2provided by MGI
Official Full Name: fidgetin-like 2provided by MGI
Primary source: MGI:MGI:3646919
See related: Ensembl:ENSMUSG00000095440 AllianceGenome:MGI:3646919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EG668225
Summary: Predicted to enable ATP hydrolysis activity and microtubule severing ATPase activity. Predicted to be involved in microtubule severing and negative regulation of cell migration. Predicted to be located in cell leading edge. Orthologous to human FIGNL2 (fidgetin like 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in ovary adult (RPKM 6.5), adrenal adult (RPKM 5.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 56.39 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100948075..100976465, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101050192..101078584, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.
Title: Fidgetin-like 2 negatively regulates axonal growth and can be targeted to promote functional nerve regeneration.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule severing ATPase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule severing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell leading edge	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fidgetin-like protein 2

NP_001201840.1

EC 3.6.4.-

XP_006521346.1

EC 3.6.4.-

XP_006521347.1

EC 3.6.4.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001214911.3 → NP_001201840.1 fidgetin-like protein 2

See identical proteins and their annotated locations for NP_001201840.1

Status: VALIDATED

Source sequence(s)

AC104834

Consensus CDS

CCDS57012.1

UniProtKB/Swiss-Prot

J3QK54

Related

ENSMUSP00000150618.2, ENSMUST00000213610.2

Conserved Domains (1) summary

COG0464
Location:381 → 638

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

100948075..100976465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521284.1 → XP_006521347.1 fidgetin-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006521347.1

UniProtKB/Swiss-Prot

J3QK54

Conserved Domains (1) summary

COG0464
Location:381 → 638

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
XM_006521283.1 → XP_006521346.1 fidgetin-like protein 2 isoform X1

See identical proteins and their annotated locations for XP_006521346.1

UniProtKB/Swiss-Prot

J3QK54

Related

ENSMUSP00000137256.2, ENSMUST00000178140.2

Conserved Domains (1) summary

COG0464
Location:381 → 638

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_028577.1: Suppressed sequence

Description

NG_028577.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.