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    Nfrkb nuclear factor related to kappa B binding protein [ Mus musculus (house mouse) ]

    Gene ID: 235134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nfrkbprovided by MGI
    Official Full Name
    nuclear factor related to kappa B binding proteinprovided by MGI
    Primary source
    MGI:MGI:2442410
    See related
    Ensembl:ENSMUSG00000042185 AllianceGenome:MGI:2442410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A530090G11Rik
    Summary
    Predicted to enable protease binding activity. Involved in positive regulation of DNA metabolic process; regulation of embryonic development; and telomere maintenance. Predicted to be located in nucleoplasm. Predicted to be part of Ino80 complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human NFRKB (nuclear factor related to kappaB binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.3), spleen adult (RPKM 11.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nfrkb in Genome Data Viewer
    Location:
    9 A4; 9 16.86 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (31297476..31332629)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31386162..31421333)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23695 Neighboring gene PR domain containing 10 Neighboring gene predicted gene 10910 Neighboring gene STARR-seq mESC enhancer starr_23697 Neighboring gene STARR-seq mESC enhancer starr_23701 Neighboring gene RIKEN cDNA 1700023A20 gene Neighboring gene STARR-positive B cell enhancer ABC_E9326 Neighboring gene STARR-positive B cell enhancer ABC_E8852 Neighboring gene STARR-seq mESC enhancer starr_23704 Neighboring gene STARR-seq mESC enhancer starr_23705 Neighboring gene transmembrane protein 45b Neighboring gene STARR-seq mESC enhancer starr_23707 Neighboring gene U2 small nuclear ribonucleoprotein B pseudogene Neighboring gene STARR-seq mESC enhancer starr_23708 Neighboring gene STARR-seq mESC enhancer starr_23709 Neighboring gene predicted gene, 31408 Neighboring gene dihydrofolate reductase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Min JN, et al. Cell Res, 2013 Dec. PMID 23979016, Free PMC Article
    2. Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice. Nakaya N, et al. Exp Neurol, 2013 Dec. PMID 24095980, Free PMC Article
    3. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
    4. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
    5. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of telomere maintenance in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA strand elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ino80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear factor related to kappa-B-binding protein
    Names
    DNA-binding protein R kappa-B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359654.2 → NP_001346583.1  nuclear factor related to kappa-B-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167244
      Conserved Domains (3) summary
      pfam14465
      Location:149 → 233
      NFRKB_winged; NFRKB Winged Helix-like
      cl26464
      Location:489 → 660
      Atrophin-1; Atrophin-1 family
      cl27894
      Location:614 → 944
      DUF1522; Domain of Unknown Function (DUF1522)

    2. NM_001405097.1 → NP_001392026.1  nuclear factor related to kappa-B-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC167244

    3. NM_001405098.1 → NP_001392027.1  nuclear factor related to kappa-B-binding protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC167244

    4. NM_001405099.1 → NP_001392028.1  nuclear factor related to kappa-B-binding protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC167244

    5. NM_001405101.1 → NP_001392030.1  nuclear factor related to kappa-B-binding protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC167244

    6. NM_001405102.1 → NP_001392031.1  nuclear factor related to kappa-B-binding protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC167244

    7. NM_172766.4 → NP_766354.2  nuclear factor related to kappa-B-binding protein isoform 1

      See identical proteins and their annotated locations for NP_766354.2

      Status: VALIDATED

      Source sequence(s)
      AC167244
      Consensus CDS
      CCDS22949.1
      UniProtKB/Swiss-Prot
      Q6PIJ4, Q8BWV5, Q8K0X6
      Related
      ENSMUSP00000083341.6, ENSMUST00000086167.12
      Conserved Domains (1) summary
      pfam14465
      Location:392 → 476
      NFRKB_winged; NFRKB Winged Helix-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      31297476..31332629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313307.3 → XP_017168796.1  nuclear factor related to kappa-B-binding protein isoform X4

      Conserved Domains (3) summary
      PRK12688
      Location:823 → 1153
      PRK12688; flagellin; Reviewed
      PHA03247
      Location:698 → 869
      PHA03247; large tegument protein UL36; Provisional
      pfam14465
      Location:358 → 444
      NFRKB_winged; NFRKB Winged Helix-like

    2. XM_017313308.3 → XP_017168797.1  nuclear factor related to kappa-B-binding protein isoform X5

      Conserved Domains (3) summary
      PRK12688
      Location:822 → 1152
      PRK12688; flagellin; Reviewed
      PHA03247
      Location:697 → 868
      PHA03247; large tegument protein UL36; Provisional
      pfam14465
      Location:358 → 444
      NFRKB_winged; NFRKB Winged Helix-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PIJ4.1 GenPept UniProtKB/Swiss-Prot:Q6PIJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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