U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Slc6a2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 20538, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc6a2provided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2provided by MGI
    Primary source
    MGI:MGI:1270850
    See related
    Ensembl:ENSMUSG00000055368 AllianceGenome:MGI:1270850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NET; NE-T; Slc6a5
    Summary
    Enables neurotransmitter transmembrane transporter activity and norepinephrine:sodium symporter activity. Involved in neurotransmitter reuptake and norepinephrine uptake. Acts upstream of or within neurotransmitter transport and response to pain. Predicted to be located in cell surface. Predicted to be active in axon; neuronal cell body membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; lip; nervous system; renal pelvis; and sensory organ. Used to study heart conduction disease. Human ortholog(s) of this gene implicated in alcohol dependence; hypertension; and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in placenta adult (RPKM 4.2), subcutaneous fat pad adult (RPKM 4.1) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc6a2 in Genome Data Viewer
    Location:
    8 C5; 8 44.99 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93687100..93728295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (92960470..93001667)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene STARR-seq mESC enhancer starr_22327 Neighboring gene calpain, small subunit 2 Neighboring gene predicted gene 2947 Neighboring gene carboxylesterase 1A Neighboring gene STARR-seq mESC enhancer starr_22328 Neighboring gene carboxylesterase 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding  
    enables actin binding  
    enables alpha-tubulin binding  
    enables alpha-tubulin binding  
    enables beta-tubulin binding  
    enables beta-tubulin binding  
    enables dopamine:sodium symporter activity  
    enables dopamine:sodium symporter activity  
    enables dopamine:sodium symporter activity  
    enables metal ion binding  
    enables monoamine transmembrane transporter activity PubMed 
    enables monoamine transmembrane transporter activity PubMed 
    enables neurotransmitter transmembrane transporter activity PubMed 
    enables neurotransmitter:sodium symporter activity  
    enables norepinephrine:sodium symporter activity  
    enables norepinephrine:sodium symporter activity PubMed 
    enables norepinephrine:sodium symporter activity  
    Process Evidence Code Pubs
    involved_in amino acid transport  
    involved_in dopamine uptake  
    involved_in dopamine uptake involved in synaptic transmission  
    acts_upstream_of_or_within monoamine transport PubMed 
    involved_in neurotransmitter reuptake PubMed 
    involved_in neurotransmitter reuptake PubMed 
    acts_upstream_of_or_within neurotransmitter transport PubMed 
    involved_in neurotransmitter transport PubMed 
    involved_in norepinephrine transport  
    involved_in norepinephrine transport  
    involved_in norepinephrine uptake PubMed 
    acts_upstream_of_or_within response to pain PubMed 
    involved_in response to xenobiotic stimulus  
    involved_in sodium ion transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    is_active_in axon  
    located_in cell surface  
    located_in cell surface  
    is_active_in neuronal cell body membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in presynaptic membrane  
    located_in presynaptic membrane  
    located_in synaptic vesicle membrane  

    General protein information

    Preferred Names
    sodium-dependent noradrenaline transporter
    Names
    NE transporter
    norepinephrine transporter
    solute carrier family 6 member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009209.3NP_033235.3  sodium-dependent noradrenaline transporter

      See identical proteins and their annotated locations for NP_033235.3

      Status: VALIDATED

      Source sequence(s)
      AC140217, AJ439987, AK078616, AY188506, CD551617
      Consensus CDS
      CCDS22525.1
      UniProtKB/Swiss-Prot
      O55192, Q6QU62
      UniProtKB/TrEMBL
      Q8R2I2
      Related
      ENSMUSP00000072709.7, ENSMUST00000072939.8
      Conserved Domains (1) summary
      cl00456
      Location:56615
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      93687100..93728295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530793.5XP_006530856.2  sodium-dependent noradrenaline transporter isoform X1

      UniProtKB/Swiss-Prot
      O55192, Q6QU62
      UniProtKB/TrEMBL
      Q8R2I2
      Conserved Domains (1) summary
      cl00456
      Location:56615
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_006530794.5XP_006530857.2  sodium-dependent noradrenaline transporter isoform X1

      UniProtKB/Swiss-Prot
      O55192, Q6QU62
      UniProtKB/TrEMBL
      Q8R2I2
      Conserved Domains (1) summary
      cl00456
      Location:56615
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    External link. Please review our privacy policy.