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    Nr5a2 nuclear receptor subfamily 5, group A, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 26424, updated on 17-Dec-2024

    Summary

    Official Symbol
    Nr5a2provided by MGI
    Official Full Name
    nuclear receptor subfamily 5, group A, member 2provided by MGI
    Primary source
    MGI:MGI:1346834
    See related
    Ensembl:ENSMUSG00000026398 AllianceGenome:MGI:1346834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ftf; LRH-1; UF2-H3B; D1Ertd308e
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; cholesterol homeostasis; and pancreas morphogenesis. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; ear; early conceptus; and gonad. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 23.7), liver adult (RPKM 4.6) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Nr5a2 in Genome Data Viewer
    Location:
    1 59.98 cM; 1 E4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136770300..136888186, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136842562..136960448, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase pseudogene Neighboring gene uncharacterized protein C1orf43 homolog Neighboring gene STARR-seq mESC enhancer starr_02440 Neighboring gene STARR-seq mESC enhancer starr_02441 Neighboring gene U7 small nuclear RNA, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_02444 Neighboring gene predicted gene, 25609

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables chromatin binding PubMed 
    enables double-stranded DNA binding  
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables phospholipid binding  
    enables phospholipid binding  
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription coregulator binding  
    enables transcription coregulator binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acinar cell differentiation PubMed 
    acts_upstream_of_or_within bile acid metabolic process PubMed 
    involved_in calcineurin-mediated signaling  
    involved_in calcineurin-mediated signaling  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor PubMed 
    acts_upstream_of_or_within cholesterol homeostasis PubMed 
    involved_in hormone-mediated signaling pathway  
    involved_in intracellular receptor signaling pathway  
    acts_upstream_of_or_within pancreas morphogenesis PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of viral genome replication  
    involved_in positive regulation of viral genome replication  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in tissue development  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    part_of RNA polymerase II transcription regulator complex PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    nuclear receptor subfamily 5 group A member 2
    Names
    fetoprotein transcription factor
    liver receptor homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159769.2NP_001153241.1  nuclear receptor subfamily 5 group A member 2 isoform 2

      See identical proteins and their annotated locations for NP_001153241.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (2) contains a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC124814
      Consensus CDS
      CCDS48382.1
      UniProtKB/TrEMBL
      Q1WLP7
      Related
      ENSMUSP00000141495.2, ENSMUST00000192929.6
      Conserved Domains (2) summary
      cd07069
      Location:259499
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:46138
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    2. NM_030676.3NP_109601.1  nuclear receptor subfamily 5 group A member 2 isoform 1

      See identical proteins and their annotated locations for NP_109601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC120182, AC124814, BC137845
      Consensus CDS
      CCDS15328.1
      UniProtKB/Swiss-Prot
      B9EHF9, P45448
      Related
      ENSMUSP00000027649.8, ENSMUST00000027649.14
      Conserved Domains (2) summary
      cd07069
      Location:320560
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:107199
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      136770300..136888186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529621.3XP_006529684.1  nuclear receptor subfamily 5 group A member 2 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YY04
      Related
      ENSMUSP00000142219.2, ENSMUST00000192357.6
      Conserved Domains (2) summary
      cd07069
      Location:299539
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:86178
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    2. XM_006529622.4XP_006529685.1  nuclear receptor subfamily 5 group A member 2 isoform X2

      See identical proteins and their annotated locations for XP_006529685.1

      UniProtKB/TrEMBL
      Q1WLP7
      Related
      ENSMUSP00000129071.2, ENSMUST00000168126.7
      Conserved Domains (2) summary
      cd07069
      Location:259499
      NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,
      cd07167
      Location:46138
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
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