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    Smox spermine oxidase [ Mus musculus (house mouse) ]

    Gene ID: 228608, updated on 9-Dec-2024

    Summary

    Official Symbol
    Smoxprovided by MGI
    Official Full Name
    spermine oxidaseprovided by MGI
    Primary source
    MGI:MGI:2445356
    See related
    Ensembl:ENSMUSG00000027333 AllianceGenome:MGI:2445356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PAO; SMO; PAOh1; B130066H01Rik
    Summary
    Enables polyamine oxidase activity. Acts upstream of or within spermine catabolic process. Predicted to be located in cytosol; nuclear membrane; and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including cerebral cortex; extraembryonic component; and placenta. Orthologous to human SMOX (spermine oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 27.2), liver E14 (RPKM 26.0) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Smox in Genome Data Viewer
    Location:
    2 F1; 2 63.45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (131333624..131367103)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (131491858..131525183)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10147 Neighboring gene aldo-keto reductase family 1 member A1-like Neighboring gene predicted gene 14304 Neighboring gene predicted gene, 30679 Neighboring gene STARR-seq mESC enhancer starr_05713 Neighboring gene predicted gene, 30732 Neighboring gene predicted gene, 39938 Neighboring gene adrenergic receptor, alpha 1d

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables polyamine oxidase activity  
    enables polyamine oxidase activity PubMed 
    enables polyamine oxidase activity  
    enables spermine oxidase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nuclear membrane  
    located_in nuclear membrane  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    spermine oxidase
    Names
    PAO-1
    polyamine oxidase 1
    NP_001171304.1
    NP_001171305.1
    NP_001171306.1
    NP_001171307.1
    NP_001171308.1
    NP_001171309.1
    NP_001171310.1
    NP_001171311.1
    NP_663508.1
    XP_006499350.1
    XP_006499351.1
    XP_006499352.1
    XP_006499353.1
    XP_006499354.1
    XP_006499355.1
    XP_006499356.1
    XP_011237777.1
    XP_017173258.1
    XP_030106328.1
    XP_030106330.1
    XP_030106332.1
    XP_030106336.1
    XP_030106341.1
    XP_030106346.1
    XP_030106347.1
    XP_030106354.1
    XP_030106358.1
    XP_030106360.1
    XP_030106369.1
    XP_030106371.1
    XP_030106373.1
    XP_036017254.1
    XP_036017255.1
    XP_036017256.1
    XP_036017258.1
    XP_036017259.1
    XP_036017261.1
    XP_036017262.1
    XP_036017263.1
    XP_036017264.1
    XP_036017276.1
    XP_036017285.1
    XP_036017288.1
    XP_036017293.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177833.2NP_001171304.1  spermine oxidase isoform a

      See identical proteins and their annotated locations for NP_001171304.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript and it encodes the longest protein (isoform a). This variant has also been called 'splice variant mu'.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS50719.1
      UniProtKB/Swiss-Prot
      Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Related
      ENSMUSP00000105815.3, ENSMUST00000110186.9
      Conserved Domains (1) summary
      PLN02568
      Location:50578
      PLN02568; polyamine oxidase
    2. NM_001177834.2NP_001171305.1  spermine oxidase isoform c

      See identical proteins and their annotated locations for NP_001171305.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different splice site and lacks an alternate exon, which shifts the reading frame, compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus when it is compared to isoform a. This variant has also been called 'splice variant beta'.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS50720.1
      UniProtKB/Swiss-Prot
      Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Related
      ENSMUSP00000105817.2, ENSMUST00000110188.8
      Conserved Domains (2) summary
      PLN02568
      Location:50457
      PLN02568; polyamine oxidase
      pfam13450
      Location:4588
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    3. NM_001177835.2NP_001171306.1  spermine oxidase isoform d

      See identical proteins and their annotated locations for NP_001171306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons which shifts the reading frame, compared to variant 1. The resulting protein (isoform d) is shorter and has a distinct C-terminus when it is compared to isoform a. This transcript has also been called 'splice variant gamma'.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS50721.1
      UniProtKB/Swiss-Prot
      Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Related
      ENSMUSP00000105818.3, ENSMUST00000110189.9
      Conserved Domains (1) summary
      PLN02568
      Location:50445
      PLN02568; polyamine oxidase
    4. NM_001177836.2NP_001171307.1  spermine oxidase isoform e

      See identical proteins and their annotated locations for NP_001171307.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses a different splice site and lacks an alternate, in-frame exon, compared to variant 1. The resulting protein (isoform e) is shorter when it is compared to isoform a. This transcript and protein have also been called 'polyamine oxidase-m'.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS50718.1
      UniProtKB/Swiss-Prot
      Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Related
      ENSMUSP00000105809.2, ENSMUST00000110180.2
      Conserved Domains (1) summary
      PLN02568
      Location:50412
      PLN02568; polyamine oxidase
    5. NM_001177837.2NP_001171308.1  spermine oxidase isoform f

      See identical proteins and their annotated locations for NP_001171308.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses a different splice site and lacks an alternate, in-frame exon, compared to variant 1. The resulting protein (isoform f) is shorter when it is compared to isoform a.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS50722.1
      UniProtKB/TrEMBL
      Q3TLR8
      Related
      ENSMUSP00000105810.2, ENSMUST00000110181.8
      Conserved Domains (2) summary
      pfam01593
      Location:45374
      Amino_oxidase; Flavin containing amine oxidoreductase
      pfam13450
      Location:4588
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    6. NM_001177838.2NP_001171309.1  spermine oxidase isoform g

      See identical proteins and their annotated locations for NP_001171309.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks three alternate exons but maintains the reading frame, compared to variant 1. The resulting protein (isoform g) is shorter when it is compared to isoform a. This transcript has also been called 'splice variant phi'.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS50724.1
      UniProtKB/Swiss-Prot
      Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Related
      ENSMUSP00000105812.3, ENSMUST00000110183.9
      Conserved Domains (1) summary
      pfam13450
      Location:4588
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    7. NM_001177839.2NP_001171310.1  spermine oxidase isoform h

      See identical proteins and their annotated locations for NP_001171310.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) lacks two alternate exons, which changes the reading frame and results in a premature stop codon, compared to variant 1. The resulting protein (isoform h) has a shorter and distinct C-terminus when it is compared to isoform a. This transcript has also been called 'splice variant epsilon' and 'polyamine oxidase-s'.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS50723.1
      UniProtKB/TrEMBL
      A2ANQ4
      Related
      ENSMUSP00000105808.3, ENSMUST00000110179.9
      Conserved Domains (1) summary
      pfam01593
      Location:45193
      Amino_oxidase; Flavin containing amine oxidoreductase
    8. NM_001177840.2NP_001171311.1  spermine oxidase isoform i

      See identical proteins and their annotated locations for NP_001171311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) lacks four alternate exons but maintains the reading frame, compared to variant 1. The resulting protein (isoform i) is shorter when it is compared to isoform a. This transcript has also been called 'splice variant delta'.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS50725.1
      UniProtKB/Swiss-Prot
      Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Related
      ENSMUSP00000105811.3, ENSMUST00000110182.9
      Conserved Domains (1) summary
      pfam13450
      Location:4588
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
    9. NM_145533.3NP_663508.1  spermine oxidase isoform b

      See identical proteins and their annotated locations for NP_663508.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a. This transcript and protein have also been called 'polyamine oxidase-l'.
      Source sequence(s)
      AL831731, AL831781
      Consensus CDS
      CCDS16763.1
      UniProtKB/Swiss-Prot
      A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9, Q70LB0, Q8CJ56, Q8CJ57, Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Related
      ENSMUSP00000028806.6, ENSMUST00000028806.12
      Conserved Domains (1) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      131333624..131367103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161366.1XP_036017259.1  spermine oxidase isoform X2

      Conserved Domains (1) summary
      PLN02568
      Location:50577
      PLN02568; polyamine oxidase
    2. XM_036161365.1XP_036017258.1  spermine oxidase isoform X1

      Conserved Domains (1) summary
      PLN02568
      Location:50578
      PLN02568; polyamine oxidase
    3. XM_036161371.1XP_036017264.1  spermine oxidase isoform X3

      UniProtKB/Swiss-Prot
      A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9, Q70LB0, Q8CJ56, Q8CJ57, Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Conserved Domains (1) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase
    4. XM_006499290.3XP_006499353.1  spermine oxidase isoform X5

      Conserved Domains (1) summary
      PLN02568
      Location:50513
      PLN02568; polyamine oxidase
    5. XM_006499293.4XP_006499356.1  spermine oxidase isoform X12

      Conserved Domains (1) summary
      PLN02568
      Location:50403
      PLN02568; polyamine oxidase
    6. XM_017317769.2XP_017173258.1  spermine oxidase isoform X14

      Conserved Domains (1) summary
      PLN02568
      Location:50373
      PLN02568; polyamine oxidase
    7. XM_030250476.2XP_030106336.1  spermine oxidase isoform X4

      Conserved Domains (1) summary
      PLN02568
      Location:50547
      PLN02568; polyamine oxidase
    8. XM_006499291.2XP_006499354.1  spermine oxidase isoform X8

      Conserved Domains (1) summary
      PLN02568
      Location:50442
      PLN02568; polyamine oxidase
    9. XM_036161395.1XP_036017288.1  spermine oxidase isoform X15

      Conserved Domains (1) summary
      PLN02568
      Location:50266
      PLN02568; polyamine oxidase
    10. XM_006499289.5XP_006499352.1  spermine oxidase isoform X2

      Conserved Domains (1) summary
      PLN02568
      Location:50577
      PLN02568; polyamine oxidase
    11. XM_006499287.4XP_006499350.1  spermine oxidase isoform X1

      See identical proteins and their annotated locations for XP_006499350.1

      UniProtKB/Swiss-Prot
      Q99K82
      Conserved Domains (1) summary
      PLN02568
      Location:50578
      PLN02568; polyamine oxidase
    12. XM_030250468.1XP_030106328.1  spermine oxidase isoform X3

      UniProtKB/Swiss-Prot
      A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9, Q70LB0, Q8CJ56, Q8CJ57, Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Conserved Domains (1) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase
    13. XM_030250500.1XP_030106360.1  spermine oxidase isoform X11

      Conserved Domains (1) summary
      PLN02568
      Location:50411
      PLN02568; polyamine oxidase
    14. XM_011239475.3XP_011237777.1  spermine oxidase isoform X16

      Conserved Domains (2) summary
      PLN02568
      Location:226271
      PLN02568; polyamine oxidase
      pfam01593
      Location:45115
      Amino_oxidase; Flavin containing amine oxidoreductase
    15. XM_030250509.1XP_030106369.1  spermine oxidase isoform X13

      Conserved Domains (1) summary
      PLN02568
      Location:43400
      PLN02568; polyamine oxidase
    16. XM_030250487.2XP_030106347.1  spermine oxidase isoform X7

      Conserved Domains (1) summary
      PLN02568
      Location:50444
      PLN02568; polyamine oxidase
    17. XM_006499292.4XP_006499355.1  spermine oxidase isoform X9

      Conserved Domains (1) summary
      PLN02568
      Location:43430
      PLN02568; polyamine oxidase
    18. XM_036161370.1XP_036017263.1  spermine oxidase isoform X3

      UniProtKB/Swiss-Prot
      A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9, Q70LB0, Q8CJ56, Q8CJ57, Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Conserved Domains (1) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase
    19. XM_036161383.1XP_036017276.1  spermine oxidase isoform X10

      Conserved Domains (1) summary
      PLN02568
      Location:50412
      PLN02568; polyamine oxidase
    20. XM_036161363.1XP_036017256.1  spermine oxidase isoform X1

      Conserved Domains (1) summary
      PLN02568
      Location:50578
      PLN02568; polyamine oxidase
    21. XM_036161400.1XP_036017293.1  spermine oxidase isoform X17

      UniProtKB/TrEMBL
      A2ANQ4
      Conserved Domains (1) summary
      pfam01593
      Location:45193
      Amino_oxidase; Flavin containing amine oxidoreductase
    22. XM_036161361.1XP_036017254.1  spermine oxidase isoform X1

      Conserved Domains (1) summary
      PLN02568
      Location:50578
      PLN02568; polyamine oxidase
    23. XM_030250513.2XP_030106373.1  spermine oxidase isoform X17

      UniProtKB/TrEMBL
      A2ANQ4
      Conserved Domains (1) summary
      pfam01593
      Location:45193
      Amino_oxidase; Flavin containing amine oxidoreductase
    24. XM_030250472.2XP_030106332.1  spermine oxidase isoform X3

      UniProtKB/Swiss-Prot
      A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9, Q70LB0, Q8CJ56, Q8CJ57, Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Conserved Domains (1) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase
    25. XM_036161368.1XP_036017261.1  spermine oxidase isoform X3

      UniProtKB/Swiss-Prot
      A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9, Q70LB0, Q8CJ56, Q8CJ57, Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Conserved Domains (1) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase
    26. XM_030250470.1XP_030106330.1  spermine oxidase isoform X3

      UniProtKB/Swiss-Prot
      A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9, Q70LB0, Q8CJ56, Q8CJ57, Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Conserved Domains (1) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase
    27. XM_006499288.3XP_006499351.1  spermine oxidase isoform X1

      See identical proteins and their annotated locations for XP_006499351.1

      UniProtKB/Swiss-Prot
      Q99K82
      Conserved Domains (1) summary
      PLN02568
      Location:50578
      PLN02568; polyamine oxidase
    28. XM_030250486.1XP_030106346.1  spermine oxidase isoform X6

      Conserved Domains (1) summary
      PLN02568
      Location:50445
      PLN02568; polyamine oxidase
    29. XM_030250494.1XP_030106354.1  spermine oxidase isoform X8

      Conserved Domains (1) summary
      PLN02568
      Location:50442
      PLN02568; polyamine oxidase
    30. XM_030250498.1XP_030106358.1  spermine oxidase isoform X10

      Conserved Domains (1) summary
      PLN02568
      Location:50412
      PLN02568; polyamine oxidase
    31. XM_036161392.1XP_036017285.1  spermine oxidase isoform X12

      Conserved Domains (1) summary
      PLN02568
      Location:50403
      PLN02568; polyamine oxidase
    32. XM_030250511.2XP_030106371.1  spermine oxidase isoform X17

      UniProtKB/TrEMBL
      A2ANQ4
      Conserved Domains (1) summary
      pfam01593
      Location:45193
      Amino_oxidase; Flavin containing amine oxidoreductase
    33. XM_030250481.1XP_030106341.1  spermine oxidase isoform X4

      Conserved Domains (1) summary
      PLN02568
      Location:50547
      PLN02568; polyamine oxidase
    34. XM_036161362.1XP_036017255.1  spermine oxidase isoform X1

      Conserved Domains (1) summary
      PLN02568
      Location:50578
      PLN02568; polyamine oxidase
    35. XM_036161369.1XP_036017262.1  spermine oxidase isoform X3

      UniProtKB/Swiss-Prot
      A2ANQ8, A2ANQ9, A2ANR0, A2ANR1, A2ANR2, Q70LA3, Q70LA4, Q70LA5, Q70LA7, Q70LA8, Q70LA9, Q70LB0, Q8CJ56, Q8CJ57, Q99K82
      UniProtKB/TrEMBL
      Q3UPW5
      Conserved Domains (1) summary
      PLN02568
      Location:50548
      PLN02568; polyamine oxidase

    RNA

    1. XR_374452.3 RNA Sequence

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