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    Radil Ras association and DIL domains [ Mus musculus (house mouse) ]

    Gene ID: 231858, updated on 9-Dec-2024

    Summary

    Official Symbol
    Radilprovided by MGI
    Official Full Name
    Ras association and DIL domainsprovided by MGI
    Primary source
    MGI:MGI:2443088
    See related
    Ensembl:ENSMUSG00000029576 AllianceGenome:MGI:2443088
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D930005D10Rik
    Summary
    Predicted to enable GTPase binding activity. Predicted to be involved in neural crest cell migration and substrate adhesion-dependent cell spreading. Predicted to be part of protein-containing complex. Predicted to be active in microtubule. Is expressed in testis. Orthologous to human RADIL (Rap associating with DIL domain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 12.8), lung adult (RPKM 12.5) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Radil in Genome Data Viewer
    Location:
    5 G2; 5 81.53 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142470594..142536873, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142483795..142551098, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene forkhead box K1 Neighboring gene predicted gene, 54310 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:142915875-142916058 Neighboring gene STARR-positive B cell enhancer ABC_E4804 Neighboring gene STARR-positive B cell enhancer ABC_E2771 Neighboring gene STARR-seq mESC enhancer starr_14747 Neighboring gene adaptor-related protein complex 5, zeta 1 subunit Neighboring gene predicted gene, 38732 Neighboring gene poly (A) polymerase beta (testis specific) Neighboring gene STARR-positive B cell enhancer ABC_E8090 Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene predicted gene, 31274

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in microtubule  
    located_in microtubule PubMed 
    part_of protein-containing complex  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    ras-associating and dilute domain-containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289588.1NP_001276517.1  ras-associating and dilute domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001276517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AI536456, AK162917, BY201066
      Consensus CDS
      CCDS71698.1
      UniProtKB/TrEMBL
      D3YWJ9
      Related
      ENSMUSP00000106412.2, ENSMUST00000110785.2
      Conserved Domains (4) summary
      cd00992
      Location:9921076
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:411778
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      cd17116
      Location:50161
      RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
      pfam00498
      Location:273343
      FHA; FHA domain
    2. NM_001310752.1NP_001297681.1  ras-associating and dilute domain-containing protein isoform 3

      See identical proteins and their annotated locations for NP_001297681.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AI536456, AK052964, AK083410
      Consensus CDS
      CCDS80453.1
      UniProtKB/Swiss-Prot
      Q69Z89, Q8BNL0, Q8C549, Q8C6X2, Q8CAL1
      Related
      ENSMUSP00000082910.4, ENSMUST00000085758.10
      Conserved Domains (4) summary
      cd00992
      Location:9981082
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:440807
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:302372
      FHA; FHA domain
      pfam00788
      Location:90193
      RA; Ras association (RalGDS/AF-6) domain
    3. NM_178702.4NP_848817.2  ras-associating and dilute domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_848817.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site inthe 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI536456, BC056483, BY201066
      Consensus CDS
      CCDS19827.1
      UniProtKB/Swiss-Prot
      Q69Z89
      Related
      ENSMUSP00000064539.9, ENSMUST00000063635.15
      Conserved Domains (4) summary
      cd00992
      Location:9691053
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:411778
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:273343
      FHA; FHA domain
      pfam00788
      Location:61164
      RA; Ras association (RalGDS/AF-6) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      142470594..142536873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504685.5XP_006504748.1  ras-associating and dilute domain-containing protein isoform X2

      See identical proteins and their annotated locations for XP_006504748.1

      UniProtKB/TrEMBL
      D3YWJ9
      Conserved Domains (4) summary
      cd00992
      Location:9921076
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:411778
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      cd17116
      Location:50161
      RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
      pfam00498
      Location:273343
      FHA; FHA domain
    2. XM_006504682.4XP_006504745.1  ras-associating and dilute domain-containing protein isoform X1

      Conserved Domains (4) summary
      cd00992
      Location:10211105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:440807
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      cd17116
      Location:79190
      RA_Radil_like; Ras-associating (RA) domain found in ras-associating and dilute domain-containing protein (Radil) and similar proteins
      pfam00498
      Location:302372
      FHA; FHA domain
    3. XM_030254449.2XP_030110309.1  ras-associating and dilute domain-containing protein isoform X5

      Conserved Domains (2) summary
      cd00992
      Location:475559
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:1284
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
    4. XM_030254445.2XP_030110305.1  ras-associating and dilute domain-containing protein isoform X3

      Conserved Domains (3) summary
      cd00992
      Location:752836
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:171538
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:33103
      FHA; FHA domain
    5. XM_030254446.2XP_030110306.1  ras-associating and dilute domain-containing protein isoform X3

      Conserved Domains (3) summary
      cd00992
      Location:752836
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:171538
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:33103
      FHA; FHA domain
    6. XM_006504686.4XP_006504749.1  ras-associating and dilute domain-containing protein isoform X4

      See identical proteins and their annotated locations for XP_006504749.1

      UniProtKB/Swiss-Prot
      Q69Z89
      Related
      ENSMUSP00000106411.2, ENSMUST00000110784.8
      Conserved Domains (3) summary
      cd00992
      Location:729813
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:171538
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:33103
      FHA; FHA domain
    7. XM_030254447.2XP_030110307.1  ras-associating and dilute domain-containing protein isoform X4

      Conserved Domains (3) summary
      cd00992
      Location:729813
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:171538
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:33103
      FHA; FHA domain
    8. XM_030254444.2XP_030110304.1  ras-associating and dilute domain-containing protein isoform X3

      Conserved Domains (3) summary
      cd00992
      Location:752836
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:171538
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:33103
      FHA; FHA domain

    RNA

    1. XR_004942508.1 RNA Sequence

      Related
      ENSMUST00000139824.2
    2. XR_001784688.3 RNA Sequence

    3. XR_377156.5 RNA Sequence

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