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    Itih5 inter-alpha-trypsin inhibitor, heavy chain 5 [ Mus musculus (house mouse) ]

    Gene ID: 209378, updated on 24-Dec-2024

    Summary

    Official Symbol
    Itih5provided by MGI
    Official Full Name
    inter-alpha-trypsin inhibitor, heavy chain 5provided by MGI
    Primary source
    MGI:MGI:1925751
    See related
    Ensembl:ENSMUSG00000025780 AllianceGenome:MGI:1925751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130106B02; 4631408O11Rik; 5430408M01Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process and negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in several structures, including genitourinary system; gut; limb segment; meninges; and sensory organ. Orthologous to human ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 41.5), subcutaneous fat pad adult (RPKM 34.7) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Itih5 in Genome Data Viewer
    Location:
    2 A1; 2 6.94 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10158354..10261340)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10153536..10256529)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha trypsin inhibitor, heavy chain 2 Neighboring gene STARR-seq mESC enhancer starr_03643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:10236348-10236535 Neighboring gene predicted gene, 31496 Neighboring gene predicted gene, 39758

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    General protein information

    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H5
    Names
    ITI heavy chain H5
    ITI-HC5
    inter-alpha (globulin) inhibitor H5
    inter-alpha trypsin inhibitor heavy chain precursor 5
    inter-alpha-inhibitor heavy chain 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172471.2NP_766059.1  inter-alpha-trypsin inhibitor heavy chain H5 precursor

      See identical proteins and their annotated locations for NP_766059.1

      Status: VALIDATED

      Source sequence(s)
      AK087428, AL953853, AW046694, BB595829
      Consensus CDS
      CCDS15678.1
      UniProtKB/Swiss-Prot
      Q3US68, Q80VG0, Q8BJD1
      Related
      ENSMUSP00000026886.8, ENSMUST00000026886.8
      Conserved Domains (4) summary
      cd01461
      Location:292473
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:65620
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam06668
      Location:716909
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      pfam08487
      Location:51157
      VIT; Vault protein inter-alpha-trypsin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      10158354..10261340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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