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    Foxl3 forkhead box L3 [ Mus musculus (house mouse) ]

    Gene ID: 384244, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Foxl3provided by MGI
    Official Full Name
    forkhead box L3provided by MGI
    Primary source
    MGI:MGI:3646467
    See related
    Ensembl:ENSMUSG00000094504 AllianceGenome:MGI:3646467
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5294; EG384244
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Orthologous to human FOXL3-OT1 (FOXL3 overlapping transcript 1) and FOXL3 (forkhead box L3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 3.0), testis adult (RPKM 0.7) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Foxl3 in Genome Data Viewer
    Location:
    5; 5 G2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138805640..138807486)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138819865..138821731)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A430033K04 gene Neighboring gene STARR-positive B cell enhancer ABC_E1314 Neighboring gene STARR-seq mESC enhancer starr_14671 Neighboring gene STARR-seq mESC enhancer starr_14672 Neighboring gene STARR-seq mESC enhancer starr_14673 Neighboring gene FAM20C, golgi associated secretory pathway kinase Neighboring gene STARR-seq mESC enhancer starr_14674 Neighboring gene predicted gene, 30206 Neighboring gene predicted gene, 31891 Neighboring gene STARR-seq mESC enhancer starr_14676

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    forkhead box L3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195128.1 → NP_001182057.1  forkhead box L3

      Status: INFERRED

      Source sequence(s)
      AC113533
      Consensus CDS
      CCDS57394.1
      UniProtKB/TrEMBL
      J3QP53
      Related
      ENSMUSP00000137099.2, ENSMUST00000179205.2
      Conserved Domains (1) summary
      pfam00250
      Location:32 → 118
      Forkhead; Forkhead domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138805640..138807486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504717.4 → XP_006504780.1  forkhead box L3 isoform X1

      Conserved Domains (2) summary
      COG5025
      Location:20 → 196
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      pfam00250
      Location:31 → 118
      Forkhead; Forkhead domain
    Nucleotide Protein
    Heading Accession and Version

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