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    Nsun4 NOL1/NOP2/Sun domain family, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 72181, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nsun4provided by MGI
    Official Full Name
    NOL1/NOP2/Sun domain family, member 4provided by MGI
    Primary source
    MGI:MGI:1919431
    See related
    Ensembl:ENSMUSG00000028706 AllianceGenome:MGI:1919431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Shtap; 2310010O12Rik; 2810405F18Rik
    Summary
    Enables small ribosomal subunit rRNA binding activity. Involved in cytosolic ribosome assembly; positive regulation of mitochondrial translation; and rRNA methylation. Located in mitochondrion. Is expressed in several structures, including branchial arch; central nervous system; limb bud; neural ectoderm; and sensory organ. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 57.2) and heart adult (RPKM 3.5) See more
    Orthologs
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    Genomic context

    See Nsun4 in Genome Data Viewer
    Location:
    4 D1; 4 53.1 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115890202..115911076, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116033002..116053879, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38492 Neighboring gene STARR-seq mESC enhancer starr_11131 Neighboring gene fatty acid amide hydrolase Neighboring gene STARR-positive B cell enhancer ABC_E3503 Neighboring gene STARR-positive B cell enhancer ABC_E4647 Neighboring gene predicted gene 12854 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene leucine rich repeat containing 41 Neighboring gene predicted gene, 52704

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA (cytidine-5-)-methyltransferase activity  
    enables rRNA (cytosine-C5-)-methyltransferase activity  
    enables rRNA methyltransferase activity  
    enables small ribosomal subunit rRNA binding PubMed 
    enables tRNA (cytidine-5-)-methyltransferase activity  
    enables tRNA (cytidine-5-)-methyltransferase activity  
    enables tRNA binding  
    Process Evidence Code Pubs
    involved_in cytosolic ribosome assembly PubMed 
    involved_in mitochondrial RNA catabolic process  
    involved_in positive regulation of mitochondrial translation PubMed 
    involved_in rRNA methylation PubMed 
    involved_in rRNA methylation  
    involved_in tRNA methylation  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    part_of mitochondrial large ribosomal subunit PubMed 
    located_in mitochondrial matrix  
    located_in mitochondrion PubMed 
    is_active_in nucleus  

    General protein information

    Preferred Names
    putative methyltransferase NSUN4
    Names
    5-methylcytosine tRNA methyltransferase NSUN4
    sperm head and tail associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369075.1NP_001356004.1  putative methyltransferase NSUN4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
      Source sequence(s)
      AL627105
      Conserved Domains (1) summary
      COG0144
      Location:103274
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
    2. NM_001369076.1NP_001356005.1  putative methyltransferase NSUN4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AL627105
      Conserved Domains (1) summary
      COG0144
      Location:103274
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
    3. NM_028142.5NP_082418.1  putative methyltransferase NSUN4 isoform a

      See identical proteins and their annotated locations for NP_082418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AL627105
      Consensus CDS
      CCDS18502.1
      UniProtKB/Swiss-Prot
      Q9CZ57, Q9D7F0
      Related
      ENSMUSP00000030475.2, ENSMUST00000030475.3
      Conserved Domains (1) summary
      cl17173
      Location:163322
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115890202..115911076 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003955016.2 RNA Sequence

    2. XR_376358.4 RNA Sequence

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