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    Kbtbd4 kelch repeat and BTB (POZ) domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 67136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kbtbd4provided by MGI
    Official Full Name
    kelch repeat and BTB (POZ) domain containing 4provided by MGI
    Primary source
    MGI:MGI:1914386
    See related
    Ensembl:ENSMUSG00000005505 AllianceGenome:MGI:1914386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510026C23Rik
    Summary
    Is expressed in several structures, including central nervous system; metanephros; node; retina; and trigeminal nerve. Orthologous to human KBTBD4 (kelch repeat and BTB domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 12.4), whole brain E14.5 (RPKM 11.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kbtbd4 in Genome Data Viewer
    Location:
    2 E1; 2 50.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90735113..90740905)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90904740..90910561)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 32514 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S3 Neighboring gene predicted gene, 54113 Neighboring gene protein tyrosine phosphatase, mitochondrial 1 Neighboring gene STARR-seq mESC enhancer starr_05099 Neighboring gene CUGBP, Elav-like family member 1 Neighboring gene STARR-seq mESC enhancer starr_05101 Neighboring gene STARR-positive B cell enhancer mm9_chr2:90854051-90854352

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection. Sousa-Nunes R, et al. Genome Res, 2003 Dec. PMID 14613977, Free PMC Article
    2. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    4. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    kelch repeat and BTB domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311116.2 → NP_001298045.1  kelch repeat and BTB domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001298045.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL672241
      Consensus CDS
      CCDS79820.1
      UniProtKB/Swiss-Prot
      A2AFW3, Q8R179, Q9CQX1
      Related
      ENSMUSP00000107089.2, ENSMUST00000111464.8
      Conserved Domains (6) summary
      smart00225
      Location:62 → 156
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14733
      Location:158 → 216
      BACK_like; BTB-And-C-terminal-Kelch (BACK) domain and similar domains
      TIGR03548
      Location:370 → 527
      mutarot_permut; cyclically-permuted mutarotase family protein
      sd00038
      Location:295 → 330
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:55 → 154
      BTB; BTB/POZ domain
      pfam07646
      Location:294 → 330
      Kelch_2; Kelch motif

    2. NM_001361372.2 → NP_001348301.1  kelch repeat and BTB domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672241
      Consensus CDS
      CCDS16419.1
      Conserved Domains (4) summary
      PHA03098
      Location:47 → 479
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:279 → 314
      Kelch; KELCH repeat [structural motif]
      cd18272
      Location:13 → 152
      BTB_POZ_KBTBD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)
      cd18481
      Location:142 → 229
      BACK_KBTBD4; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)

    3. NM_025991.5 → NP_080267.1  kelch repeat and BTB domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_080267.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL672241
      Consensus CDS
      CCDS16419.1
      UniProtKB/Swiss-Prot
      Q8R179
      Related
      ENSMUSP00000088179.4, ENSMUST00000090682.4
      Conserved Domains (4) summary
      PHA03098
      Location:47 → 479
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:279 → 314
      Kelch; KELCH repeat [structural motif]
      cd18272
      Location:13 → 152
      BTB_POZ_KBTBD4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)
      cd18481
      Location:142 → 229
      BACK_KBTBD4; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      90735113..90740905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R179.1 GenPept UniProtKB/Swiss-Prot:Q8R179

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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