Ttll6 tubulin tyrosine ligase-like family, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttll6provided by MGI
Official Full Name: tubulin tyrosine ligase-like family, member 6provided by MGI
Primary source: MGI:MGI:2683461
See related: Ensembl:ENSMUSG00000038756 AllianceGenome:MGI:2683461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: t8130b59; D11Moh43e; D11Moh44e; 4932418K24Rik
Summary: Enables tubulin binding activity and tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation and regulation of cilium beat frequency involved in ciliary motility. Acts upstream of or within microtubule bundle formation; microtubule severing; and positive regulation of cilium movement. Located in 9+0 non-motile cilium and ciliary basal body. Is expressed in several structures, including branchial arch; early embryo; genitourinary system; inner ear; and primitive streak. Orthologous to human TTLL6 (tubulin tyrosine ligase like 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 23.0), colon adult (RPKM 7.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.48 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96015283..96057008)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96124457..96166182)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Title: Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
Transgenic mice overexpressing Tau show TTLL6 translocalization into dendrites and decreased MT stability
Title: Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.
The polyglutamylase TTLL6 plays a key role in the regulation of ciliary beating.
Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.
Ttll6 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-glutamic acid ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-glutamic acid ligase activity, elongating	IEA Inferred from Electronic Annotation more info
enables protein-glutamic acid ligase activity, initiating	IEA Inferred from Electronic Annotation more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IDA Inferred from Direct Assay more info	PubMed
enables tubulin-glutamic acid ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin-glutamic acid ligase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule bundle formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule bundle formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within microtubule severing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within microtubule severing	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein polyglutamylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyglutamylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cilium beat frequency involved in ciliary motility	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in 9+0 non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulin polyglutamylase TTLL6

Names: polyglutamylase; protein polyglutamylase TTLL6; tubulin--tyrosine ligase-like protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172799.5 → NP_766387.2 tubulin polyglutamylase TTLL6

See identical proteins and their annotated locations for NP_766387.2

Status: VALIDATED

Source sequence(s)

AL603682

Consensus CDS

CCDS25290.2

UniProtKB/Swiss-Prot

A2A6M6, A4Q9E8, B2RQS4, Q3UL10, Q8BVQ1

Related

ENSMUSP00000127778.2, ENSMUST00000167258.8

Conserved Domains (1) summary

pfam03133
Location:105 → 385

TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

96015283..96057008

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314531.2 → XP_017170020.1 tubulin polyglutamylase TTLL6 isoform X1

UniProtKB/TrEMBL

B9EJA6

Related

ENSMUSP00000103307.2, ENSMUST00000107680.2

Conserved Domains (1) summary

pfam03133
Location:1 → 281

TTL; Tubulin-tyrosine ligase family
XM_017314532.2 → XP_017170021.1 tubulin polyglutamylase TTLL6 isoform X2

Conserved Domains (1) summary

pfam03133
Location:1 → 281

TTL; Tubulin-tyrosine ligase family