Btn2a2 butyrophilin, subfamily 2, member A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Btn2a2provided by MGI
Official Full Name: butyrophilin, subfamily 2, member A2provided by MGI
Primary source: MGI:MGI:3606486
See related: Ensembl:ENSMUSG00000053216 AllianceGenome:MGI:3606486
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Btn2; D030063K05
Summary: Predicted to enable signaling receptor binding activity. Involved in negative regulation of activated T cell proliferation and negative regulation of cytokine production. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of signal transduction; and positive regulation of regulatory T cell differentiation. Located in cell surface. Orthologous to several human genes including BTN2A2 (butyrophilin subfamily 2 member A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 13 A3.1; 13 9.74 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (23661219..23673028, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (23477049..23488858, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.
Title: Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.
Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses.
Title: Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses.
RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption.
Title: RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption.
Btn2a2(-/-) mice exhibited enhanced effector CD4(+) and CD8(+) T cell responses, impaired CD4(+) regulatory T cell induction, potentiated antitumor responses, and exacerbated experimental autoimmune encephalomyelitis.
Title: Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.
These data are consistent with a coinhibitory role for mouse Butyrophilins
Title: BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of regulatory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokine production	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: butyrophilin subfamily 2 member A2

Names: butyrophilin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289614.1 → NP_001276543.1 butyrophilin subfamily 2 member A2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001276543.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1, and encodes a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AL714025, BC141341, CJ065534

Consensus CDS

CCDS88423.1

UniProtKB/TrEMBL

B9EJ60

Related

ENSMUSP00000153680.2, ENSMUST00000223877.2

Conserved Domains (4) summary

cd05713
Location:45 → 144

Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

smart00410
Location:38 → 143

IG_like; Immunoglobulin like

cd15819
Location:305 → 473

SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)

cl11960
Location:149 → 229

Ig; Immunoglobulin domain
NM_001289615.1 → NP_001276544.1 butyrophilin subfamily 2 member A2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001276544.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3 encode the same isoform.

Source sequence(s)

AL714025, BC139760, CJ065534

Consensus CDS

CCDS36619.1

UniProtKB/Swiss-Prot

A4QPC6, Q811T8

Related

ENSMUSP00000106062.2, ENSMUST00000110432.2

Conserved Domains (3) summary

cd15819
Location:312 → 482

SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)

cd05713
Location:45 → 144

Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

cl11960
Location:165 → 236

Ig; Immunoglobulin domain
NM_175938.3 → NP_787952.2 butyrophilin subfamily 2 member A2 isoform 1 precursor

See identical proteins and their annotated locations for NP_787952.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same isoform.

Source sequence(s)

AK051061, AL714025, CJ065534

Consensus CDS

CCDS36619.1

UniProtKB/Swiss-Prot

A4QPC6, Q811T8

Related

ENSMUSP00000106063.4, ENSMUST00000110433.10

Conserved Domains (3) summary

cd15819
Location:312 → 482

SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)

cd05713
Location:45 → 144

Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

cl11960
Location:165 → 236

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

23661219..23673028 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516664.1 → XP_006516727.1 butyrophilin subfamily 2 member A2 isoform X1

See identical proteins and their annotated locations for XP_006516727.1

UniProtKB/Swiss-Prot

A4QPC6, Q811T8

Conserved Domains (3) summary

cd15819
Location:312 → 482

SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)

cd05713
Location:45 → 144

Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

cl11960
Location:165 → 236

Ig; Immunoglobulin domain
XM_036158037.1 → XP_036013930.1 butyrophilin subfamily 2 member A2 isoform X2

Conserved Domains (1) summary

cd15819
Location:159 → 329

SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
XM_017315508.1 → XP_017170997.1 butyrophilin subfamily 2 member A2 isoform X3

Conserved Domains (2) summary

cd05713
Location:45 → 144

Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)

cl11960
Location:165 → 236

Ig; Immunoglobulin domain