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    Zfp958 zinc finger protein 958 [ Mus musculus (house mouse) ]

    Gene ID: 233987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp958provided by MGI
    Official Full Name
    zinc finger protein 958provided by MGI
    Primary source
    MGI:MGI:2385298
    See related
    Ensembl:ENSMUSG00000058748 AllianceGenome:MGI:2385298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in heart; limb; and limb mesenchyme. Orthologous to several human genes including ZNF117 (zinc finger protein 117); ZNF490 (zinc finger protein 490); and ZNF708 (zinc finger protein 708). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 1.7), bladder adult (RPKM 1.5) and 24 other tissues See more
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    Genomic context

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    See Zfp958 in Genome Data Viewer
    Location:
    8 A1.1; 8 2.07 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4663170..4682572)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4613170..4632572)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ceramide synthase 4 Neighboring gene STARR-seq mESC enhancer starr_20617 Neighboring gene vomeronasal 2, receptor, pseudogene 89 Neighboring gene STARR-seq mESC enhancer starr_20618 Neighboring gene STARR-seq mESC enhancer starr_20619 Neighboring gene STARR-seq mESC enhancer starr_20620 Neighboring gene serine/threonine kinase 38 like pseudogene Neighboring gene predicted gene, 30502

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 878

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368404.1 → NP_001355333.1  zinc finger protein 878 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC155814
      Conserved Domains (3) summary
      COG5048
      Location:125 → 484
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:26 → 66
      KRAB; KRAB box

    2. NM_001368405.1 → NP_001355334.1  zinc finger protein 878 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC155814
      Related
      ENSMUSP00000072937.6, ENSMUST00000073201.6
      Conserved Domains (2) summary
      COG5048
      Location:71 → 430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:157 → 177
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_145591.5 → NP_663566.1  zinc finger protein 878 isoform 2

      See identical proteins and their annotated locations for NP_663566.1

      Status: VALIDATED

      Source sequence(s)
      AC155814
      Consensus CDS
      CCDS80856.1
      UniProtKB/TrEMBL
      Q99LG7
      Related
      ENSMUSP00000143842.2, ENSMUST00000202692.5
      Conserved Domains (5) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      COG5048
      Location:103 → 462
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:189 → 209
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:257 → 281
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      4663170..4682572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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