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    Abcc5 ATP-binding cassette, sub-family C member 5 [ Mus musculus (house mouse) ]

    Gene ID: 27416, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Abcc5provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family C member 5provided by MGI
    Primary source
    MGI:MGI:1351644
    See related
    Ensembl:ENSMUSG00000022822 AllianceGenome:MGI:1351644
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mrp5; Abcc5a; Abcc5b; 2900011L11Rik
    Summary
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 26.0), CNS E14 (RPKM 23.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Abcc5 in Genome Data Viewer
    Location:
    16 A3; 16 12.41 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20150053..20245178, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20331303..20426428, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene presenilin associated, rhomboid-like Neighboring gene cytochrome P450, family 2, subfamily ab, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_40320 Neighboring gene STARR-seq mESC enhancer starr_40322 Neighboring gene STARR-seq mESC enhancer starr_40323 Neighboring gene predicted gene, 41432 Neighboring gene STARR-seq mESC enhancer starr_40326 Neighboring gene STARR-seq mESC enhancer starr_40327 Neighboring gene STARR-seq mESC enhancer starr_40328 Neighboring gene eukaryotic translation initiation factor 2B, subunit 5 epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of hyaluronan export from human fibroblasts by inhibitors of multidrug resistance transporters. Prehm P, et al. Biochem Pharmacol, 2004 Oct 1. PMID 15345330
    2. Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1. Cyranka M, et al. Obesity (Silver Spring), 2019 Aug. PMID 31338999, Free PMC Article
    3. Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump. Meissner K, et al. Shock, 2007 Nov. PMID 17589384
    4. An exercise-inducible metabolite that suppresses feeding and obesity. Li VL, et al. Nature, 2022 Jun. PMID 35705806, Free PMC Article
    5. MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function. Chambers IG, et al. Proc Natl Acad Sci U S A, 2022 Feb 8. PMID 35121660, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.
      Title: MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.
    2. ABCC5 is a general glutamate conjugate and analog transporter that affects the disposition of endogenous metabolites, toxins, and drugs.
      Title: ATP-binding Cassette Subfamily C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs.
    3. Deficiency of MKP5 resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 critically controls inflammation in white adipose tissue and the development of metabolic disorders
      Title: Regulation of Adipose Tissue Inflammation and Insulin Resistance by MAPK Phosphatase 5.
    4. Reduced cGMP export as a consequence of decreased MRP5 expression can attenuate heart failure in sepsis.
      Title: Sepsis affects cardiac expression of multidrug resistance protein 5 (MRP5, ABCC5), an ABC-type CGMP export pump.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ABC-type transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables ABC-type xenobiotic transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ABC-type xenobiotic transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate derivative transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbohydrate derivative transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables macromolecule transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables macromolecule transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables purine nucleotide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables purine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cAMP transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cGMP transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in folate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in folate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutathione transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heme transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hyaluronan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hyaluronan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in purine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 5
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 5
    ATP-binding cassette, sub-family C (CFTR/MRP), member 5a
    ATP-binding cassette, sub-family C (CFTR/MRP), member 5b
    MOAT-C
    SMRP
    multi-specific organic anion transporter C
    multidrug resistance-associated protein 5
    NP_038818.2
    NP_789809.1
    XP_006522271.1
    XP_006522272.1
    XP_006522275.1
    XP_006522276.1
    XP_006522277.1
    XP_006522278.1
    XP_017172518.1
    XP_030105004.1
    XP_030105005.1
    XP_030105006.1
    XP_030105007.1
    XP_030105008.1
    XP_036015866.1
    XP_036015868.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013790.2 → NP_038818.2  ATP-binding cassette sub-family C member 5 isoform 1

      See identical proteins and their annotated locations for NP_038818.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BB603250, BC090629
      Consensus CDS
      CCDS28045.1
      UniProtKB/Swiss-Prot
      O88284, Q5CZY2, Q9R1X5
      Related
      ENSMUSP00000078158.7, ENSMUST00000079158.13
      Conserved Domains (1) summary
      PLN03130
      Location:100 → 1424
      PLN03130; ABC transporter C family member; Provisional

    2. NM_176839.1 → NP_789809.1  ATP-binding cassette sub-family C member 5 isoform 2

      See identical proteins and their annotated locations for NP_789809.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons but has two alternate 3' exons, as compared to variant 1. The encoded isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      BB603250, BC061132
      Consensus CDS
      CCDS28046.1
      UniProtKB/TrEMBL
      Q6P8Q2, Q8CFP9
      Related
      ENSMUSP00000093913.5, ENSMUST00000096199.5
      Conserved Domains (1) summary
      PLN03232
      Location:100 → 156
      PLN03232; ABC transporter C family member; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20150053..20245178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522209.5 → XP_006522272.1  ATP-binding cassette sub-family C member 5 isoform X2

      Conserved Domains (1) summary
      PLN03130
      Location:59 → 1383
      PLN03130; ABC transporter C family member; Provisional

    2. XM_030249146.2 → XP_030105006.1  ATP-binding cassette sub-family C member 5 isoform X3

      Conserved Domains (1) summary
      PLN03130
      Location:45 → 1168
      PLN03130; ABC transporter C family member; Provisional

    3. XM_030249145.2 → XP_030105005.1  ATP-binding cassette sub-family C member 5 isoform X3

      Conserved Domains (1) summary
      PLN03130
      Location:45 → 1168
      PLN03130; ABC transporter C family member; Provisional

    4. XM_036159973.1 → XP_036015866.1  ATP-binding cassette sub-family C member 5 isoform X3

      Conserved Domains (1) summary
      PLN03130
      Location:45 → 1168
      PLN03130; ABC transporter C family member; Provisional

    5. XM_017317029.3 → XP_017172518.1  ATP-binding cassette sub-family C member 5 isoform X4

      Conserved Domains (1) summary
      PLN03130
      Location:103 → 952
      PLN03130; ABC transporter C family member; Provisional

    6. XM_006522213.5 → XP_006522276.1  ATP-binding cassette sub-family C member 5 isoform X4

      See identical proteins and their annotated locations for XP_006522276.1

      Conserved Domains (1) summary
      PLN03130
      Location:103 → 952
      PLN03130; ABC transporter C family member; Provisional

    7. XM_006522212.5 → XP_006522275.1  ATP-binding cassette sub-family C member 5 isoform X4

      See identical proteins and their annotated locations for XP_006522275.1

      Conserved Domains (1) summary
      PLN03130
      Location:103 → 952
      PLN03130; ABC transporter C family member; Provisional

    8. XM_006522208.4 → XP_006522271.1  ATP-binding cassette sub-family C member 5 isoform X1

      See identical proteins and their annotated locations for XP_006522271.1

      UniProtKB/Swiss-Prot
      O88284, Q5CZY2, Q9R1X5
      Conserved Domains (1) summary
      PLN03130
      Location:100 → 1424
      PLN03130; ABC transporter C family member; Provisional

    9. XM_030249144.2 → XP_030105004.1  ATP-binding cassette sub-family C member 5 isoform X2

      Conserved Domains (1) summary
      PLN03130
      Location:59 → 1383
      PLN03130; ABC transporter C family member; Provisional

    10. XM_006522215.2 → XP_006522278.1  ATP-binding cassette sub-family C member 5 isoform X5

      See identical proteins and their annotated locations for XP_006522278.1

      UniProtKB/TrEMBL
      Q6P8Q2, Q8CFP9
      Conserved Domains (1) summary
      PLN03232
      Location:100 → 156
      PLN03232; ABC transporter C family member; Provisional

    11. XM_006522214.2 → XP_006522277.1  ATP-binding cassette sub-family C member 5 isoform X5

      See identical proteins and their annotated locations for XP_006522277.1

      UniProtKB/TrEMBL
      Q6P8Q2, Q8CFP9
      Conserved Domains (1) summary
      PLN03232
      Location:100 → 156
      PLN03232; ABC transporter C family member; Provisional

    12. XM_036159975.1 → XP_036015868.1  ATP-binding cassette sub-family C member 5 isoform X5

      UniProtKB/TrEMBL
      Q6P8Q2, Q8CFP9
      Conserved Domains (1) summary
      PLN03232
      Location:100 → 156
      PLN03232; ABC transporter C family member; Provisional

    13. XM_030249148.2 → XP_030105008.1  ATP-binding cassette sub-family C member 5 isoform X5

      UniProtKB/TrEMBL
      Q6P8Q2, Q8CFP9
      Conserved Domains (1) summary
      PLN03232
      Location:100 → 156
      PLN03232; ABC transporter C family member; Provisional

    14. XM_030249147.2 → XP_030105007.1  ATP-binding cassette sub-family C member 5 isoform X5

      UniProtKB/TrEMBL
      Q6P8Q2, Q8CFP9
      Conserved Domains (1) summary
      PLN03232
      Location:100 → 156
      PLN03232; ABC transporter C family member; Provisional

    RNA

    1. XR_384569.1 RNA Sequence

    2. XR_384568.1 RNA Sequence

    3. XR_001781835.3 RNA Sequence

    4. XR_001781832.3 RNA Sequence

    5. XR_001781834.3 RNA Sequence

    6. XR_001781836.3 RNA Sequence

    7. XR_001781833.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R1X5.2 GenPept UniProtKB/Swiss-Prot:Q9R1X5

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