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    Uty ubiquitously transcribed tetratricopeptide repeat containing, Y-linked [ Mus musculus (house mouse) ]

    Gene ID: 22290, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Utyprovided by MGI
    Official Full Name
    ubiquitously transcribed tetratricopeptide repeat containing, Y-linkedprovided by MGI
    Primary source
    MGI:MGI:894810
    See related
    Ensembl:ENSMUSG00000068457 AllianceGenome:MGI:894810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hydb; mKIAA4057
    Summary
    Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and histone H3K36 demethylase activity. Acts upstream of or within several processes, including cardiac muscle cell contraction; heterochromatin formation; and in utero embryonic development. Part of protein-containing complex. Is expressed in several structures, including alimentary system; early conceptus; forelimb bud; genitourinary system; and liver. Orthologous to human UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 1.8), CNS E14 (RPKM 1.7) and 18 other tissues See more
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    Genomic context

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    See Uty in Genome Data Viewer
    Location:
    Y; Ypter
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) Y NC_000087.8 (1085187..1245787, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) Y NC_000087.7 (1085187..1245773, complement)

    Chromosome Y - NC_000087.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Neighboring gene STARR-seq mESC enhancer starr_48297 Neighboring gene testis specific protein-Y encoded, pseudogene Neighboring gene STARR-seq mESC enhancer starr_48298 Neighboring gene DEAD box helicase 3, Y-linked Neighboring gene predicted gene 4017 Neighboring gene ring finger and WD repeat domain 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure. Horitani K, et al. Nat Cardiovasc Res, 2024 Mar. PMID 39183958, Free PMC Article
    2. The male minor transplantation antigen preferentially activates recipient CD4+ T cells through the indirect presentation pathway in vivo. Chen Y, et al. J Immunol, 2003 Dec 15. PMID 14662851
    3. TALEN-mediated editing of the mouse Y chromosome. Wang H, et al. Nat Biotechnol, 2013 Jun. PMID 23666012, Free PMC Article
    4. CD4 cells can be more efficient at tumor rejection than CD8 cells. Perez-Diez A, et al. Blood, 2007 Jun 15. PMID 17327412, Free PMC Article
    5. Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons. Xu J, et al. J Neurosci, 2008 Apr 23. PMID 18434530, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure.
      Title: Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure.
    2. Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cells.
      Title: Regulatory effects of the Uty/Ddx3y locus on neighboring chromosome Y genes and autosomal mRNA transcripts in adult mouse non-reproductive cells.
    3. Our data suggest that UTX and UTY are able to regulate gene activity through demethylase independent mechanisms
      Title: UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.
    4. UTX controls mesoderm differentiation and Brachyury expression independent of H3K27 demethylase activity; UTX and UTY are functionally redundant in ES cell differentiation and early embryonic development
      Title: UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity.
    5. Regional brain expression of the Y-linked paralogue Uty is distinct from that of Utx, specifically in the paraventricular nucleus of the hypothalamus (high Uty) and the amygdala (high Utx).
      Title: Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.
    6. Activation of T cell receptor-transgenic T cells preferentially occurs through cognate interactions with a peptide determinant derived from the HYDb male antigen, which is expressed on recipient antigen presenting cells after heart transplantation.
      Title: The male minor transplantation antigen preferentially activates recipient CD4+ T cells through the indirect presentation pathway in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4057

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27me2/H3K27me3 demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K27me2/H3K27me3 demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K36 demethylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone demethylase UTY
    Names
    [histone H3]-trimethyl-L-lysine(27) demethylase UTY
    male-specific histocompatibility antigen H-YDB
    ubiquitously transcribed TPR protein on the Y chromosome
    ubiquitously transcribed Y chromosome tetratricopeptide repeat protein
    ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
    NP_001313611.1
    NP_001313612.1
    NP_001406755.1
    NP_001406756.1
    NP_001406757.1
    NP_001406758.1
    NP_001406759.1
    NP_033510.2
    XP_006531650.1
    XP_011246883.1
    XP_011246884.1
    XP_011246885.1
    XP_011246886.1
    XP_011246887.1
    XP_011246888.1
    XP_011246891.1
    XP_017174175.1
    XP_017174176.1
    XP_017174177.1
    XP_017174178.1
    XP_030107425.1
    XP_036018083.1
    XP_036018084.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326682.2 → NP_001313611.1  histone demethylase UTY isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      Consensus CDS
      CCDS85834.1
      UniProtKB/Swiss-Prot
      O97979, P79457
      UniProtKB/TrEMBL
      E9PWW8
      Related
      ENSMUSP00000114752.2, ENSMUST00000139365.8
      Conserved Domains (7) summary
      pfam02373
      Location:944 → 1052
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:910 → 974
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:279 → 306
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:124 → 157
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:311 → 372
      TPR_11; TPR repeat
      pfam13424
      Location:274 → 342
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:266 → 297
      TPR_17; Tetratricopeptide repeat

    2. NM_001326683.2 → NP_001313612.1  histone demethylase UTY isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      Consensus CDS
      CCDS85833.1
      UniProtKB/Swiss-Prot
      O97979, P79457
      UniProtKB/TrEMBL
      Q3UQE8
      Related
      ENSMUSP00000114910.2, ENSMUST00000154004.8
      Conserved Domains (7) summary
      pfam02373
      Location:882 → 990
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:848 → 912
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:217 → 244
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:62 → 95
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:249 → 310
      TPR_11; TPR repeat
      pfam13424
      Location:212 → 280
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:204 → 235
      TPR_17; Tetratricopeptide repeat

    3. NM_001419826.1 → NP_001406755.1  histone demethylase UTY isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319

    4. NM_001419827.1 → NP_001406756.1  histone demethylase UTY isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319

    5. NM_001419828.1 → NP_001406757.1  histone demethylase UTY isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319

    6. NM_001419829.1 → NP_001406758.1  histone demethylase UTY isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319

    7. NM_001419830.1 → NP_001406759.1  histone demethylase UTY isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319

    8. NM_009484.4 → NP_033510.2  histone demethylase UTY isoform 1

      See identical proteins and their annotated locations for NP_033510.2

      Status: VALIDATED

      Source sequence(s)
      AC145571, AC148319
      Consensus CDS
      CCDS41216.1
      UniProtKB/Swiss-Prot
      O97979, P79457
      UniProtKB/TrEMBL
      G3X9F2
      Related
      ENSMUSP00000070012.8, ENSMUST00000069309.14
      Conserved Domains (7) summary
      pfam02373
      Location:945 → 1053
      JmjC; JmjC domain, hydroxylase
      smart00558
      Location:911 → 975
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      sd00006
      Location:280 → 307
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:125 → 158
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:312 → 373
      TPR_11; TPR repeat
      pfam13424
      Location:275 → 343
      TPR_12; Tetratricopeptide repeat
      pfam13431
      Location:267 → 298
      TPR_17; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000087.8 Reference GRCm39 C57BL/6J

      Range
      1085187..1245787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248585.4 → XP_011246887.1  histone demethylase UTY isoform X9

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:935 → 999
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:130 → 397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304 → 331
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:969 → 1077
      JmjC; JmjC domain, hydroxylase

    2. XM_011248583.2 → XP_011246885.1  histone demethylase UTY isoform X5

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:916 → 980
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:111 → 378
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285 → 312
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:950 → 1058
      JmjC; JmjC domain, hydroxylase

    3. XM_036162190.1 → XP_036018083.1  histone demethylase UTY isoform X13

      UniProtKB/TrEMBL
      E9Q504
      Related
      ENSMUSP00000115113.2, ENSMUST00000143286.8
      Conserved Domains (4) summary
      smart00558
      Location:862 → 926
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:97 → 369
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:276 → 303
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:896 → 1004
      JmjC; JmjC domain, hydroxylase

    4. XM_011248582.4 → XP_011246884.1  histone demethylase UTY isoform X4

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:931 → 995
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:126 → 393
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:300 → 327
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:965 → 1073
      JmjC; JmjC domain, hydroxylase

    5. XM_030251565.2 → XP_030107425.1  histone demethylase UTY isoform X15

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:848 → 912
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:38 → 310
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:217 → 244
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:882 → 990
      JmjC; JmjC domain, hydroxylase

    6. XM_011248581.4 → XP_011246883.1  histone demethylase UTY isoform X3

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:932 → 996
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:127 → 394
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:301 → 328
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:966 → 1074
      JmjC; JmjC domain, hydroxylase

    7. XM_017318687.3 → XP_017174176.1  histone demethylase UTY isoform X2

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:934 → 998
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:129 → 396
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:303 → 330
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:968 → 1076
      JmjC; JmjC domain, hydroxylase

    8. XM_017318688.3 → XP_017174177.1  histone demethylase UTY isoform X14

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:851 → 915
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:41 → 313
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:220 → 247
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:885 → 993
      JmjC; JmjC domain, hydroxylase

    9. XM_006531587.5 → XP_006531650.1  histone demethylase UTY isoform X18

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:886 → 950
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:101 → 373
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:280 → 307
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:920 → 1028
      JmjC; JmjC domain, hydroxylase

    10. XM_011248586.4 → XP_011246888.1  histone demethylase UTY isoform X10

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:890 → 954
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:130 → 397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304 → 331
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:924 → 1032
      JmjC; JmjC domain, hydroxylase

    11. XM_011248584.4 → XP_011246886.1  histone demethylase UTY isoform X6

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:910 → 974
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:130 → 397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304 → 331
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:944 → 1052
      JmjC; JmjC domain, hydroxylase

    12. XM_017318686.3 → XP_017174175.1  histone demethylase UTY isoform X1

      UniProtKB/Swiss-Prot
      O97979, P79457
      Conserved Domains (4) summary
      smart00558
      Location:935 → 999
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      COG0457
      Location:130 → 397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304 → 331
      TPR; TPR repeat [structural motif]
      pfam02373
      Location:969 → 1077
      JmjC; JmjC domain, hydroxylase

    13. XM_036162191.1 → XP_036018084.1  histone demethylase UTY isoform X17

      UniProtKB/TrEMBL
      Q3TNX2
      Conserved Domains (2) summary
      smart00558
      Location:448 → 512
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02373
      Location:482 → 590
      JmjC; JmjC domain, hydroxylase

    14. XM_017318689.2 → XP_017174178.1  histone demethylase UTY isoform X17

      UniProtKB/TrEMBL
      Q3TNX2
      Conserved Domains (2) summary
      smart00558
      Location:448 → 512
      JmjC; A domain family that is part of the cupin metalloenzyme superfamily
      pfam02373
      Location:482 → 590
      JmjC; JmjC domain, hydroxylase

    15. XM_011248589.4 → XP_011246891.1  histone demethylase UTY isoform X16

      Conserved Domains (2) summary
      COG0457
      Location:130 → 397
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:304 → 331
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_004940595.1 RNA Sequence

    2. XR_879400.4 RNA Sequence

    3. XR_004940593.1 RNA Sequence

    4. XR_004940592.1 RNA Sequence

    5. XR_001782882.3 RNA Sequence

      Related
      ENSMUST00000154666.8

    6. XR_004940594.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P79457.2 GenPept UniProtKB/Swiss-Prot:P79457

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