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    Zic5 zinc finger protein of the cerebellum 5 [ Mus musculus (house mouse) ]

    Gene ID: 65100, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zic5provided by MGI
    Official Full Name
    zinc finger protein of the cerebellum 5provided by MGI
    Primary source
    MGI:MGI:1929518
    See related
    Ensembl:ENSMUSG00000041703 AllianceGenome:MGI:1929518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Opr; 1700049L20Rik
    Summary
    Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within forebrain development; neural crest cell differentiation; and neural tube closure. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; limb mesenchyme; sensory organ; and trunk paraxial mesenchyme. Orthologous to human ZIC5 (Zic family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 7.5), cerebellum adult (RPKM 5.7) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zic5 in Genome Data Viewer
    Location:
    14 E5; 14 65.96 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122696572..122703127, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (122459160..122465658, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene citrate lyase beta like Neighboring gene RIKEN cDNA 1700108J01 gene Neighboring gene STARR-seq mESC enhancer starr_37753 Neighboring gene STARR-seq mESC enhancer starr_37767 Neighboring gene predicted gene 5089 Neighboring gene STARR-seq mESC enhancer starr_37772 Neighboring gene predicted gene, 25464 Neighboring gene STARR-seq mESC enhancer starr_37773 Neighboring gene STARR-seq mESC enhancer starr_37776 Neighboring gene RIKEN cDNA 2610035F20 gene Neighboring gene STARR-seq mESC enhancer starr_37778 Neighboring gene predicted gene, 53847

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein ZIC 5
    Names
    Zic family member 5 (odd-paired homolog, Drosophila)
    odd paired-related protein
    odd-paired related
    opa-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022987.3NP_075363.1  zinc finger protein ZIC 5

      Status: VALIDATED

      Source sequence(s)
      AC154683
      Consensus CDS
      CCDS27348.1
      UniProtKB/Swiss-Prot
      Q7TQ40, Q9EQW1
      UniProtKB/TrEMBL
      A0A0R4J0E2
      Related
      ENSMUSP00000035754.7, ENSMUST00000039118.7
      Conserved Domains (4) summary
      COG5048
      Location:388550
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:510534
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:466493
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      122696572..122703127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519357.5XP_006519420.1  zinc finger protein ZIC 5 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:421477
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:390408
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:437463
      zf-H2C2_2; Zinc-finger double domain
      pfam18366
      Location:360412
      zf_ZIC; Zic proteins zinc finger domain