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    Shc3 src homology 2 domain-containing transforming protein C3 [ Mus musculus (house mouse) ]

    Gene ID: 20418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Shc3provided by MGI
    Official Full Name
    src homology 2 domain-containing transforming protein C3provided by MGI
    Primary source
    MGI:MGI:106179
    See related
    Ensembl:ENSMUSG00000021448 AllianceGenome:MGI:106179
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rai; ShcC; N-Shc
    Summary
    Predicted to enable phosphotyrosine residue binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and liver and biliary system. Orthologous to human SHC3 (SHC adaptor protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 15.6), frontal lobe adult (RPKM 13.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Shc3 in Genome Data Viewer
    Location:
    13 A5; 13 26.12 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (51577422..51724909, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (51423389..51569451, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 13_636.1 Neighboring gene predicted gene, 32834 Neighboring gene STARR-seq mESC enhancer starr_34512 Neighboring gene STARR-positive B cell enhancer ABC_E8528 Neighboring gene sphingosine-1-phosphate receptor 3 Neighboring gene STARR-seq mESC enhancer starr_34513 Neighboring gene STARR-seq mESC enhancer starr_34514 Neighboring gene STARR-seq mESC enhancer starr_34516 Neighboring gene STARR-seq mESC enhancer starr_34519 Neighboring gene STARR-positive B cell enhancer ABC_E926 Neighboring gene predicted gene, 52049 Neighboring gene predicted gene, 22806 Neighboring gene CDC28 protein kinase regulatory subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential Proteomic Analysis of Astrocytes and Astrocytes-Derived Extracellular Vesicles from Control and Rai Knockout Mice: Insights into the Mechanisms of Neuroprotection. Montecchi T, et al. Int J Mol Sci, 2021 Jul 25. PMID 34360699, Free PMC Article
    2. Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation. Savino MT, et al. J Immunol, 2009 Jan 1. PMID 19109161
    3. Lack of changes in the PI3K/AKT survival pathway in the spinal cord motor neurons of a mouse model of familial amyotrophic lateral sclerosis. Peviani M, et al. Mol Cell Neurosci, 2007 Apr. PMID 17303436
    4. Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury. Rattanavich R, et al. Exp Mol Pathol, 2013 Jun. PMID 23506954, Free PMC Article
    5. The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia. Troglio F, et al. Proc Natl Acad Sci U S A, 2004 Oct 26. PMID 15494442, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential Proteomic Analysis of Astrocytes and Astrocytes-Derived Extracellular Vesicles from Control and Rai Knockout Mice: Insights into the Mechanisms of Neuroprotection.
      Title: Differential Proteomic Analysis of Astrocytes and Astrocytes-Derived Extracellular Vesicles from Control and Rai Knockout Mice: Insights into the Mechanisms of Neuroprotection.
    2. The Shc protein Rai enhances T-cell survival under hypoxia.
      Title: The Shc protein Rai enhances T-cell survival under hypoxia.
    3. Rai deficiency enhances the ability of astrocytes to upregulate the expression and activity of the ectonucleotidase CD39, which catalyzes the conversion of extracellular ATP to the immunosuppressive metabolite adenosine, through both contact-dependent and-independentmechanisms.
      Title: A T Cell Suppressive Circuitry Mediated by CD39 and Regulated by ShcC/Rai Is Induced in Astrocytes by Encephalitogenic T Cells.
    4. The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation
      Title: The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis.
    5. Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury.
      Title: Deficit of p66ShcA restores redox-sensitive stress response program in cisplatin-induced acute kidney injury.
    6. Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
      Title: Rai is a new regulator of neural progenitor migration and glioblastoma invasion.
    7. Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 to the phosphorylated subunit of the TCR/CD3 complex.
      Title: The Shc family protein adaptor, Rai, negatively regulates T cell antigen receptor signaling by inhibiting ZAP-70 recruitment and activation.
    8. TrkB-mediated ERK1/2 activation is impaired in huntingtin knock-in striatal cells involves reduced p52/p46 Shc expression
      Title: Impaired TrkB-mediated ERK1/2 activation in huntington disease knock-in striatal cells involves reduced p52/p46 Shc expression.
    9. study reports co-localization of adaptor proteins nShc & Grb10, with Kv1.3 channel in the olfactory bulb neural lamina; BDNF-induced current suppression of the Kv1.3 channel was prevented by both nShc and Grb10
      Title: Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.
    10. Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
      Title: Rai acts as a negative regulator of autoimmunity by inhibiting antigen receptor signaling and lymphocyte activation.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124163

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SHC-transforming protein 3
    Names
    SH2 domain protein C3
    SHC-transforming protein C
    neuronal Shc

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009167.5 → NP_033193.3  SHC-transforming protein 3

      Status: VALIDATED

      Source sequence(s)
      AC159104
      Consensus CDS
      CCDS49265.2
      UniProtKB/TrEMBL
      A0A5F8MPM1
      Related
      ENSMUSP00000158865.2, ENSMUST00000239056.2
      Conserved Domains (2) summary
      cd09925
      Location:492 → 594
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:139 → 310
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      51577422..51724909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157949.1 → XP_036013842.1  SHC-transforming protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A5F8MPM1
      Conserved Domains (2) summary
      cd09925
      Location:492 → 594
      SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)
      cd01209
      Location:139 → 310
      PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61120.2 GenPept UniProtKB/Swiss-Prot:Q61120

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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