Tspan7 tetraspanin 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspan7provided by MGI
Official Full Name: tetraspanin 7provided by MGI
Primary source: MGI:MGI:1298407
See related: Ensembl:ENSMUSG00000058254 AllianceGenome:MGI:1298407
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A15; Mxs1; PE31; Cd231; TALLA; Tm4sf2; 1200014P11Rik
Summary: Predicted to be involved in regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in membrane and postsynapse. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; gut; peripheral nervous system ganglion; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human TSPAN7 (tetraspanin 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 421.3), frontal lobe adult (RPKM 387.8) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 4.85 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (10351355..10462843)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (10485116..10596604)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tetraspanin 7 regulates osteoclast function through association with the RANK/alphavbeta3 integrin complex.
Title: Tetraspanin 7 regulates osteoclast function through association with the RANK/αvβ3 integrin complex.
Our results suggest that Tspan7 plays an important role in cytoskeletal organization required for the bone-resorbing function of osteoclasts by regulating signaling to Src, Pyk2, and microtubules.
Title: Effective suppression of C5a-induced proinflammatory response using anti-human C5a repebody.
Our results suggest that Tspan7 plays an important role in cytoskeletal organization required for the bone-resorbing function of osteoclasts by regulating signaling to Src, Pyk2, and microtubules.
Title: Tetraspanin 7 regulates sealing zone formation and the bone-resorbing activity of osteoclasts.
DC-STAMP, Siglec-15, Tspan7 and Mst1r expression was downregulated by docosahexaenoic acid, but not eicosapentaenoic acid during osteoclastogenesis in vitro.
Title: Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI323365 (e-PCR)
- UniSTS:181278

RH125089 (e-PCR)
- UniSTS:161911

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tetraspanin-7

Names: TALLA homolog; cell surface glycoprotein A15; transmembrane 4 superfamily member 2; tspan-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019634.2 → NP_062608.2 tetraspanin-7

See identical proteins and their annotated locations for NP_062608.2

Status: VALIDATED

Source sequence(s)

AI854904, AK004776, BY238972

Consensus CDS

CCDS30016.1

UniProtKB/Swiss-Prot

O88429, Q62283, Q9DBS3

UniProtKB/TrEMBL

Q6PDN6

Related

ENSMUSP00000075692.7, ENSMUST00000076354.13

Conserved Domains (2) summary

cd03161
Location:110 → 213

TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:15 → 237

Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

10351355..10462843

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161904.1 → XP_036017797.1 tetraspanin-7 isoform X1

UniProtKB/TrEMBL

Q8R0Q6

Conserved Domains (1) summary

cd03161
Location:24 → 127

TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...