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    Gpatch2 G patch domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 67769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpatch2provided by MGI
    Official Full Name
    G patch domain containing 2provided by MGI
    Primary source
    MGI:MGI:1915019
    See related
    Ensembl:ENSMUSG00000039210 AllianceGenome:MGI:1915019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpatc2; 5830433G22Rik; 5830436K05Rik
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Orthologous to human GPATCH2 (G-patch domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 4.4), CNS E11.5 (RPKM 2.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpatch2 in Genome Data Viewer
    Location:
    1; 1 H5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (186946855..187103839)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (187214606..187371645)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 17 Neighboring gene RIKEN cDNA 1700007P06 gene Neighboring gene STARR-seq mESC enhancer starr_03364 Neighboring gene predicted gene 15509 Neighboring gene STARR-seq mESC enhancer starr_03365 Neighboring gene STARR-positive B cell enhancer ABC_E2596 Neighboring gene predicted gene, 51737 Neighboring gene STARR-positive B cell enhancer mm9_chr1:189146346-189146647 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:189172430-189172617 Neighboring gene STARR-seq mESC enhancer starr_03368 Neighboring gene STARR-positive B cell enhancer ABC_E8782 Neighboring gene predicted gene, 37896 Neighboring gene predicted gene, 36249

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of Gpatch2 does not alter Tnf expression in mice. Dalseno D, et al. Cell Death Dis, 2023 Mar 27. PMID 36973252, Free PMC Article
    2. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deletion of Gpatch2 does not alter Tnf expression in mice.
      Title: Deletion of Gpatch2 does not alter Tnf expression in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G patch domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357645.1 → NP_001344574.1  G patch domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107843, AC108796
      Consensus CDS
      CCDS87942.1
      Related
      ENSMUSP00000124407.2, ENSMUST00000160471.8
      Conserved Domains (1) summary
      pfam01585
      Location:444 → 485
      G-patch; G-patch domain

    2. NM_001357646.1 → NP_001344575.1  G patch domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107843, AC108796
      Consensus CDS
      CCDS87941.1
      Related
      ENSMUSP00000106568.3, ENSMUST00000110943.9
      Conserved Domains (1) summary
      pfam01585
      Location:429 → 471
      G-patch; G-patch domain

    3. NM_001357647.1 → NP_001344576.1  G patch domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107843
      UniProtKB/TrEMBL
      Q3TIJ8

    4. NM_001357648.1 → NP_001344577.1  G patch domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC107843
      Consensus CDS
      CCDS87940.1
      UniProtKB/TrEMBL
      E9PY25, Q9D3E7
      Related
      ENSMUSP00000048979.6, ENSMUST00000044812.12

    5. NM_026367.4 → NP_080643.4  G patch domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_080643.4

      Status: VALIDATED

      Source sequence(s)
      AC107843, AC108796
      Consensus CDS
      CCDS15605.1
      UniProtKB/Swiss-Prot
      Q7TQC7, Q8BNJ9, Q8BPM1, Q8CDH9
      Related
      ENSMUSP00000065009.8, ENSMUST00000065573.14
      Conserved Domains (1) summary
      pfam01585
      Location:467 → 510
      G-patch; G-patch domain

    RNA

    1. NR_151741.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107843, AC108796

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      186946855..187103839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242477.2 → XP_030098337.1  G patch domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      pfam01585
      Location:444 → 485
      G-patch; G-patch domain

    2. XM_030242487.1 → XP_030098347.1  G patch domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      pfam01585
      Location:216 → 257
      G-patch; G-patch domain

    3. XM_006497199.5 → XP_006497262.1  G patch domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      M0QWF5

    4. XM_006497198.4 → XP_006497261.1  G patch domain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      M0QWF5

    5. XM_036153167.1 → XP_036009060.1  G patch domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      M0QWF5
      Related
      ENSMUSP00000137801.2, ENSMUST00000160481.8

    6. XM_030242485.1 → XP_030098345.1  G patch domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      pfam01585
      Location:216 → 257
      G-patch; G-patch domain

    RNA

    1. XR_003946457.2 RNA Sequence

    2. XR_004934119.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQC7.2 GenPept UniProtKB/Swiss-Prot:Q7TQC7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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