Obox6 oocyte specific homeobox 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Obox6provided by MGI
Official Full Name: oocyte specific homeobox 6provided by MGI
Primary source: MGI:MGI:2149036
See related: Ensembl:ENSMUSG00000041583 AllianceGenome:MGI:2149036
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D17Ertd599e
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; regulation of transcription by RNA polymerase II; and stem cell population maintenance. Predicted to be located in nucleus. Is expressed in bladder; central nervous system; early conceptus; gonad; and thymus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 7 A2; 7 8.59 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (15567175..15573604, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (15833250..15839679, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

other members of the Obox gene family can compensate for Obox6 function during embryogenesis
Title: Mice lacking the Obox6 homeobox gene undergo normal early embryonic development and are fertile.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

D17Ertd599e (e-PCR), detects polymorphism
- UniSTS:167220

AU014580 (e-PCR)
- UniSTS:179521

NoName (e-PCR)
- UniSTS:492927

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oocyte-specific homeobox protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145710.2 → NP_663756.2 oocyte-specific homeobox protein 6

See identical proteins and their annotated locations for NP_663756.2

Status: VALIDATED

Source sequence(s)

BG069935, BY731792, CN712286, CN721150

Consensus CDS

CCDS20839.2

UniProtKB/Swiss-Prot

A0PK85, G3X9U1, Q8VHG3

Related

ENSMUSP00000104153.4, ENSMUST00000108513.5

Conserved Domains (2) summary

COG5576
Location:86 → 204

COG5576; Homeodomain-containing transcription factor [Transcription]

cd00086
Location:146 → 204

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.