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    Gprin3 GPRIN family member 3 [ Mus musculus (house mouse) ]

    Gene ID: 243385, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gprin3provided by MGI
    Official Full Name
    GPRIN family member 3provided by MGI
    Primary source
    MGI:MGI:1924785
    See related
    Ensembl:ENSMUSG00000045441 AllianceGenome:MGI:1924785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C730021L23; C030038J10Rik
    Summary
    Predicted to be involved in neuron projection development. Predicted to be active in plasma membrane. Is expressed in lung. Orthologous to human GPRIN3 (GPRIN family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 1.1), lung adult (RPKM 0.9) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gprin3 in Genome Data Viewer
    Location:
    6 B3; 6 28.48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (59317988..59403291, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (59344500..59426306, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16030 Neighboring gene predicted gene, 22367 Neighboring gene STARR-seq mESC enhancer starr_16031 Neighboring gene STARR-positive B cell enhancer ABC_E4830 Neighboring gene STARR-positive B cell enhancer ABC_E8106 Neighboring gene STARR-seq mESC enhancer starr_16032 Neighboring gene STARR-seq mESC enhancer starr_16034 Neighboring gene STARR-seq mESC enhancer starr_16035 Neighboring gene tigger transposable element derived 2 Neighboring gene STARR-seq mESC enhancer starr_16038 Neighboring gene STARR-seq mESC enhancer starr_16039 Neighboring gene STARR-seq mESC enhancer starr_16041 Neighboring gene STARR-seq mESC enhancer starr_16042 Neighboring gene STARR-seq mESC enhancer starr_16043 Neighboring gene predicted gene, 35195 Neighboring gene predicted gene, 22622 Neighboring gene STARR-seq mESC enhancer starr_16044 Neighboring gene STARR-seq mESC enhancer starr_16045 Neighboring gene STARR-seq mESC enhancer starr_16047 Neighboring gene deoxycytidine kinase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of G protein-regulated inducer of neurite outgrowth 3 (GRIN3) in β-arrestin 2-Akt signaling and dopaminergic behaviors. Mototani Y, et al. Pflugers Arch, 2018 Jun. PMID 29500670
    2. GPRIN3 Controls Neuronal Excitability, Morphology, and Striatal-Dependent Behaviors in the Indirect Pathway of the Striatum. Karadurmus D, et al. J Neurosci, 2019 Sep 18. PMID 31363062, Free PMC Article
    3. Identification and biochemical analysis of GRIN1 and GRIN2. Iida N, et al. Methods Enzymol, 2004. PMID 15488195
    4. Proteomic analysis of in vivo phosphorylated synaptic proteins. Collins MO, et al. J Biol Chem, 2005 Feb 18. PMID 15572359
    5. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we identified GPRIN3 as a putative selective controller of D2R function in the striatum playing a critical role in striatal-associated behaviors and cellular functions
      Title: GPRIN3 Controls Neuronal Excitability, Morphology, and Striatal-Dependent Behaviors in the Indirect Pathway of the Striatum.
    2. GRIN3 is involved in regulation of dopamine-dependent behaviors and is essential for activation of the dopamine receptors (DAR)-beta-arrestin signaling cascade.
      Title: Role of G protein-regulated inducer of neurite outgrowth 3 (GRIN3) in β-arrestin 2-Akt signaling and dopaminergic behaviors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G protein-regulated inducer of neurite outgrowth 3
    Names
    GRIN3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183183.3 → NP_899006.1  G protein-regulated inducer of neurite outgrowth 3

      See identical proteins and their annotated locations for NP_899006.1

      Status: VALIDATED

      Source sequence(s)
      AC131708
      Consensus CDS
      CCDS20199.1
      UniProtKB/Swiss-Prot
      Q69Z30, Q8BWS5
      UniProtKB/TrEMBL
      B2RQZ6
      Related
      ENSMUSP00000051805.5, ENSMUST00000051065.6
      Conserved Domains (1) summary
      pfam15235
      Location:637 → 758
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      59317988..59403291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506084.4 → XP_006506147.2  G protein-regulated inducer of neurite outgrowth 3 isoform X1

      Conserved Domains (2) summary
      PTZ00449
      Location:565 → 709
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      pfam15235
      Location:723 → 844
      GRIN_C; G protein-regulated inducer of neurite outgrowth C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BWS5.1 GenPept UniProtKB/Swiss-Prot:Q8BWS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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