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    Slc4a9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 240215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc4a9provided by MGI
    Official Full Name
    solute carrier family 4, sodium bicarbonate cotransporter, member 9provided by MGI
    Primary source
    MGI:MGI:2443384
    See related
    Ensembl:ENSMUSG00000024485 AllianceGenome:MGI:2443384
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AE4; AE 4; D630003B07; D630024F24Rik
    Summary
    Enables sodium,bicarbonate:chloride antiporter activity and sodium:bicarbonate symporter activity. Involved in saliva secretion. Located in apical part of cell and basolateral plasma membrane. Is expressed in ureteric trunk. Orthologous to human SLC4A9 (solute carrier family 4 member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward kidney adult (RPKM 38.1) See more
    Orthologs
    human all
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    Genomic context

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    See Slc4a9 in Genome Data Viewer
    Location:
    18 B2; 18 19.46 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36661117..36689325)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36528066..36556272)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44284 Neighboring gene prefoldin 1 Neighboring gene STARR-seq mESC enhancer starr_44287 Neighboring gene STARR-seq mESC enhancer starr_44288 Neighboring gene STARR-seq mESC enhancer starr_44290 Neighboring gene heparin-binding EGF-like growth factor Neighboring gene predicted gene, 41698 Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_44296 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene Neighboring gene eukaryotic translation initiation factor 4E binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The AE4 transporter mediates kidney acid-base sensing. Vitzthum H, et al. Nat Commun, 2023 May 26. PMID 37236964, Free PMC Article
    2. Novel functions of the anion exchanger AE4 (SLC4A9). Vitzthum H, et al. Pflugers Arch, 2024 Apr. PMID 38195948, Free PMC Article
    3. The murine AE4 promoter predominantly drives type B intercalated cell specific transcription. Hentschke M, et al. Histochem Cell Biol, 2009 Oct. PMID 19544066
    4. AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct. Ko SB, et al. Am J Physiol Cell Physiol, 2002 Oct. PMID 12225984
    5. The forkhead transcription factor Foxi1 directly activates the AE4 promoter. Kurth I, et al. Biochem J, 2006 Jan 1. PMID 16159312, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel functions of the anion exchanger AE4 (SLC4A9).
      Title: Novel functions of the anion exchanger AE4 (SLC4A9).
    2. The AE4 transporter mediates kidney acid-base sensing.
      Title: The AE4 transporter mediates kidney acid-base sensing.
    3. Activation of the Ae4 (Slc4a9) cation-driven Cl(-)/HCO3(-) exchanger by the cAMP-dependent protein kinase in salivary gland acinar cells.
      Title: Activation of the Ae4 (Slc4a9) cation-driven Cl(-)/HCO(3)(-) exchanger by the cAMP-dependent protein kinase in salivary gland acinar cells.
    4. both Ae2 and Ae4 anion exchangers are functionally expressed in submandibular acinar cells; however, only Ae4 expression appears to be important for cAMP-dependent regulation of fluid secretion
      Title: Ae4 (Slc4a9) Anion Exchanger Drives Cl- Uptake-dependent Fluid Secretion by Mouse Submandibular Gland Acinar Cells.
    5. a promoter, which can recapitulate the expression of endogenous AE4 in type B intercalated cells, was identified.
      Title: The murine AE4 promoter predominantly drives type B intercalated cell specific transcription.
    6. The AE4 promoter is identified as a direct target of Foxi1.
      Title: The forkhead transcription factor Foxi1 directly activates the AE4 promoter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride:bicarbonate antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables chloride:bicarbonate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride:bicarbonate antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium,bicarbonate:chloride antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sodium:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:bicarbonate symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bicarbonate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in saliva secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical part of cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anion exchange protein 4
    Names
    anion exchanger 4
    solute carrier family 4 member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271544.1 → NP_001258473.1  anion exchange protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001258473.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK085269, AK085424, AK142545
      Consensus CDS
      CCDS89223.1
      UniProtKB/Swiss-Prot
      A0A494BA31
      UniProtKB/TrEMBL
      Q14DJ1
      Related
      ENSMUSP00000157862.2, ENSMUST00000236124.2
      Conserved Domains (3) summary
      TIGR00834
      Location:53 → 907
      ae; anion exchange protein
      pfam00955
      Location:349 → 860
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:84 → 300
      Band_3_cyto; Band 3 cytoplasmic domain

    2. NM_001271545.1 → NP_001258474.1  anion exchange protein 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC147220, AK085269, AK085424, AK142545, BC113179
      Consensus CDS
      CCDS70884.1
      UniProtKB/TrEMBL
      E9PUP3, Q14DJ1
      Related
      ENSMUSP00000158071.2, ENSMUST00000237174.2
      Conserved Domains (3) summary
      TIGR00834
      Location:53 → 884
      ae; anion exchange protein
      pfam00955
      Location:349 → 837
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:84 → 300
      Band_3_cyto; Band 3 cytoplasmic domain

    3. NM_001271546.1 → NP_001258475.1  anion exchange protein 4 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice junction at the 3' end of an exon compared to isoform 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC147220, AK085269, AK085424, AK142545, BC113785
      Consensus CDS
      CCDS89222.1
      UniProtKB/TrEMBL
      A0A494BBC3, Q14DJ1
      Related
      ENSMUSP00000158410.2, ENSMUST00000236126.2
      Conserved Domains (3) summary
      TIGR00834
      Location:53 → 873
      ae; anion exchange protein
      pfam00955
      Location:349 → 826
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:84 → 300
      Band_3_cyto; Band 3 cytoplasmic domain

    4. NM_001271547.1 → NP_001258476.1  anion exchange protein 4 isoform 5

      See identical proteins and their annotated locations for NP_001258476.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons and differs in the 3' UTR compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC147220, AK142545
      Consensus CDS
      CCDS89224.1
      UniProtKB/TrEMBL
      A0A494BAI0, Q3UQE1
      Related
      ENSMUSP00000158033.2, ENSMUST00000236779.2
      Conserved Domains (1) summary
      cl26877
      Location:53 → 802
      Band_3_cyto; Band 3 cytoplasmic domain

    5. NM_172830.2 → NP_766418.1  anion exchange protein 4 isoform 3

      See identical proteins and their annotated locations for NP_766418.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon, that causes a frameshift. It also lacks the next exon, which restores the correct reading frame. The resulting isoform (3) has a shorter, alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC147220, AK085269
      Consensus CDS
      CCDS29154.1
      UniProtKB/TrEMBL
      Q14DJ1, Q8BUG8
      Related
      ENSMUSP00000157460.2, ENSMUST00000235181.2
      Conserved Domains (3) summary
      TIGR00834
      Location:53 → 835
      ae; anion exchange protein
      pfam00955
      Location:385 → 788
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:84 → 300
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      36661117..36689325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525907.5 → XP_006525970.1  anion exchange protein 4 isoform X2

      UniProtKB/TrEMBL
      Q14DJ1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 874
      Band_3_cyto; Band 3 cytoplasmic domain

    2. XM_006525910.5 → XP_006525973.1  anion exchange protein 4 isoform X5

      UniProtKB/TrEMBL
      Q3UQE1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 803
      Band_3_cyto; Band 3 cytoplasmic domain

    3. XM_006525908.5 → XP_006525971.1  anion exchange protein 4 isoform X3

      UniProtKB/TrEMBL
      Q14DJ1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 856
      Band_3_cyto; Band 3 cytoplasmic domain

    4. XM_006525909.5 → XP_006525972.1  anion exchange protein 4 isoform X4

      UniProtKB/TrEMBL
      Q14DJ1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 836
      Band_3_cyto; Band 3 cytoplasmic domain

    5. XM_006525911.5 → XP_006525974.1  anion exchange protein 4 isoform X8

      UniProtKB/TrEMBL
      Q3UQE1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 803
      Band_3_cyto; Band 3 cytoplasmic domain

    6. XM_011246920.4 → XP_011245222.1  anion exchange protein 4 isoform X9

      UniProtKB/TrEMBL
      Q3UQE1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 803
      Band_3_cyto; Band 3 cytoplasmic domain

    7. XM_017317896.3 → XP_017173385.1  anion exchange protein 4 isoform X7

      UniProtKB/TrEMBL
      Q14DJ1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 805
      Band_3_cyto; Band 3 cytoplasmic domain

    8. XM_006525906.5 → XP_006525969.1  anion exchange protein 4 isoform X1

      UniProtKB/TrEMBL
      Q14DJ1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 908
      Band_3_cyto; Band 3 cytoplasmic domain

    9. XM_011246919.4 → XP_011245221.1  anion exchange protein 4 isoform X6

      See identical proteins and their annotated locations for XP_011245221.1

      UniProtKB/TrEMBL
      A0A494BAI0, Q3UQE1
      Conserved Domains (1) summary
      cl26877
      Location:53 → 802
      Band_3_cyto; Band 3 cytoplasmic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A494BA31.1 GenPept UniProtKB/Swiss-Prot:A0A494BA31

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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