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    Zdhhc14 zinc finger, DHHC domain containing 14 [ Mus musculus (house mouse) ]

    Gene ID: 224454, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zdhhc14provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 14provided by MGI
    Primary source
    MGI:MGI:2653229
    See related
    Ensembl:ENSMUSG00000034265 AllianceGenome:MGI:2653229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    New1cp; B530001K09Rik
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in oocyte. Orthologous to human ZDHHC14 (zinc finger DHHC-type palmitoyltransferase 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 3.4), thymus adult (RPKM 3.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc14 in Genome Data Viewer
    Location:
    17 A1; 17 3.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (5542220..5810517)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (5492562..5753891)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr17:5429429-5429729 Neighboring gene transmembrane protein 242 Neighboring gene predicted gene 29050 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:5440198-5440381 Neighboring gene lactate dehydrogenase A-like 6B Neighboring gene STARR-positive B cell enhancer ABC_E3179 Neighboring gene non-SMC condensin II complex, subunit H2 pseudogene Neighboring gene predicted gene, 52310 Neighboring gene predicted gene, 52305 Neighboring gene STARR-seq mESC enhancer starr_41701 Neighboring gene predicted gene, 53971 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:5700808-5701009 Neighboring gene STARR-positive B cell enhancer ABC_E11626 Neighboring gene predicted gene, 41519 Neighboring gene RIKEN cDNA 3300005D01 gene Neighboring gene STARR-positive B cell enhancer ABC_E7485 Neighboring gene STARR-positive B cell enhancer ABC_E10931

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Sanders SS, et al. Elife, 2020 Nov 13. PMID 33185190, Free PMC Article
    2. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Inagawa M, et al. Mech Dev, 2013 Nov-Dec. PMID 23892084
    3. Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice. Jung H, et al. Nat Neurosci, 2018 Sep. PMID 30104731
    4. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
    5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
      Title: The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC29194

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC14
    Names
    DHHC domain-containing cysteine-rich protein 14
    DHHC-14
    NEW1 domain containing protein
    probable palmitoyltransferase ZDHHC14
    zinc finger DHHC domain-containing protein 14
    NP_666185.3
    XP_006523277.1
    XP_006523278.1
    XP_006523279.1
    XP_011244479.1
    XP_017172893.1
    XP_017172894.1
    XP_017172896.1
    XP_036016400.1
    XP_036016401.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146073.3 → NP_666185.3  palmitoyltransferase ZDHHC14

      Status: VALIDATED

      Source sequence(s)
      AK036699, AK041496, AK041648, AK046719, AK080845
      Consensus CDS
      CCDS37422.1
      UniProtKB/Swiss-Prot
      Q8BNR2, Q8BQQ1, Q8CFN0
      Related
      ENSMUSP00000086589.5, ENSMUST00000089185.6
      Conserved Domains (1) summary
      pfam01529
      Location:164 → 289
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      5542220..5810517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160508.1 → XP_036016401.1  palmitoyltransferase ZDHHC14 isoform X6

      Conserved Domains (1) summary
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    2. XM_006523216.5 → XP_006523279.1  palmitoyltransferase ZDHHC14 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    3. XM_036160507.1 → XP_036016400.1  palmitoyltransferase ZDHHC14 isoform X5

      Conserved Domains (1) summary
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    4. XM_006523214.4 → XP_006523277.1  palmitoyltransferase ZDHHC14 isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:314 → 471
      PHA03247; large tegument protein UL36; Provisional
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    5. XM_006523215.4 → XP_006523278.1  palmitoyltransferase ZDHHC14 isoform X2

      Conserved Domains (1) summary
      cl19890
      Location:164 → 241
      DHHC; DHHC palmitoyltransferase

    6. XM_017317404.3 → XP_017172893.1  palmitoyltransferase ZDHHC14 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    7. XM_011246177.4 → XP_011244479.1  palmitoyltransferase ZDHHC14 isoform X4

      Conserved Domains (1) summary
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    8. XM_017317405.2 → XP_017172894.1  palmitoyltransferase ZDHHC14 isoform X7

      Conserved Domains (2) summary
      PHA03247
      Location:103 → 275
      PHA03247; large tegument protein UL36; Provisional
      cl19890
      Location:1 → 76
      DHHC; DHHC palmitoyltransferase

    9. XM_017317407.3 → XP_017172896.1  palmitoyltransferase ZDHHC14 isoform X7

      Conserved Domains (2) summary
      PHA03247
      Location:103 → 275
      PHA03247; large tegument protein UL36; Provisional
      cl19890
      Location:1 → 76
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQQ1.1 GenPept UniProtKB/Swiss-Prot:Q8BQQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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